Evidence mapPaperPMID 15467773Full record

ArticleInternational journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity2004

Measurement of abdominal fat by CT compared to waist circumference and BMI in explaining the presence of coronary calcium.

J K Snell-Bergeon, J E Hokanson, G L Kinney, D Dabelea, J Ehrlich, R H Eckel, L Ogden, M Rewers

2 registry-linked trialsAbstract readComparative StudyEvaluation Study
PubMed Publisher
In one paragraph

Article in International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01881828 phase3completedstarted 2013, after this paper: background citation

A Randomized Trial of Metformin as Adjunct Therapy for Overweight Adolescents With Type 1 Diabetes

Ran2013Enrolled164Registered outcomes16Posted comparisons0ConditionsType 1 DiabetesArmsMetformin (glucophage), oral placebo
Open the trial in the graph
NCT02045290 phase3completedstarted 2014, after this paper: background citation

Metformin Therapy for Overweight Adolescents With Type 1 Diabetes (T1D)--Insulin Clamp Ancillary Study for Assessment of Insulin Resistance

Ran2014Enrolled37Registered outcomes3Posted comparisons0ConditionsType 1 DiabetesArmsMetformin, Placebo
Open the trial in the graph
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 51 citations in OpenAlex.

  1. Outcome after neoadjuvant chemoradiation and correlation with nutritional status in patients with locally advanced pancreatic cancer.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2013
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  11. Association of apolipoprotein B, apolipoprotein A, and the its ratio with body fat distribution.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

J K Snell-BergeonDepartment of Preventive Medicine & Biometrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA. Janet.Snell-Bergeon@uchsc.edu
J E Hokanson
G L Kinney
D Dabelea
J Ehrlich
R H Eckel
L Ogden
M Rewers
University of Colorado Health · USImaging Center · USZimmer Biomet (United States) · US

Funding

ZOPOLRESTAT PHARMACOKINETICS IN DIABETICS WITH VARYING RENAL FUNCTIONM01RR000051 · UNIVERSITY OF COLORADO DENVER · 1985 to 2005
$37.2M
UCHSC DIABETES ENDOCRINOLOGY RESEARCH CENTERP30DK057516 · UNIVERSITY OF COLORADO DENVER · 2000 to 2005
$7.4M
SUBCLINICAL HEART DISEASE IN INSULIN-DEPENDENT DIABETESR01HL061753 · UNIVERSITY OF COLORADO DENVER · 1999 to 2005
$3.8M
NCRR NIH HHS M01 RR00051NHLBI NIH HHS R01 HL61753NIDDK NIH HHS P30 DK57516
6 · The paper itself

Abstract

objectiveTo evaluate the association between standard and computed tomography (CT)-based measures of obesity and subclinical atherosclerosis, defined as coronary artery calcium (CAC) by Electron Beam Computed Tomography (EBCT).

designCross-sectional, observational study of anthropometric and CT obesity measures and presence of CAC. SUBJECTS: Participants were 383 men and 379 women, aged 20-58 y and asymptomatic for coronary artery disease (CAD). MEASUREMENTS: Intra-abdominal fat (IAF) and subcutaneous fat (SQF) were measured at the level of lumbar 2-3 and 4-5 spaces, using EBCT. Body mass index (BMI) was calculated from height and weight, and minimum waist circumference and maximum hip circumference were measured. CAC was measured by EBCT.

resultsIn both men and women, BMI, waist circumference, IAF, and SQF were significantly related to CAC. However, BMI or waist circumference explained variation in the presence of CAC as well as IAF or SQF, univariately and after adjustment for additional cardiovascular risk factors.

conclusionCT-based obesity exposure measures are not superior to BMI or waist circumference in association studies of subclinical CAD.

Indexed as

Abdominal WallAdipose TissueAdultAnthropometryBody Mass IndexCalciumCoronary Artery DiseaseCoronary VesselsCross-Sectional StudiesFemaleHumansMaleMiddle AgedObesityRadiography, AbdominalSex DistributionCalcium

Identifiers

PMID15467773
OpenAlexW1963956111

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.