ArticleArchives of disease in childhood2005
Prevalence of the insulin resistance syndrome in obesity.
Article in Archives of disease in childhood, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
88 citing papers in PubMed, 2 syntheses or guidelines pooled it, 337 citations in OpenAlex.
- Prevalence of metabolic syndrome and its components in Brazilian adolescents: a systematic review and meta-analysis.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2022Pooled it
- ANTHROPOMETRY AND CLUSTERED CARDIOMETABOLIC RISK FACTORS IN YOUNG PEOPLE: A SYSTEMATIC REVIEW.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao PauloPooled it
- Parent and child dietary changes in a 6-month mobile-delivered weight loss intervention with tailored messaging for parents.Frontiers in public health · 2022Trial
- Shifts in BMI category and associated cardiometabolic risk: prospective results from HEALTHY study.Pediatrics · 2012Trial
- Trial
- Trial
- HEALTHY study rationale, design and methods: moderating risk of type 2 diabetes in multi-ethnic middle school students.International journal of obesity (2005) · 2009Trial
- A non-invasive tool for the early identification of children at risk of cardiometabolic dysfunction: data from the PODiaCar project.Pediatric research · 2026Article
- Metabolic dysfunction and insulin resistance in depression: mechanisms, evidence, and therapeutic implications.Frontiers in psychiatry · 2026Review
- Xiehuang San Extract Attenuates Insulin Resistance in Obese Rats via Gut Microbiota Modulation: Experimental Evidence.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Protein intake and insulin-like growth factor-1 at 12 months and associations with growth, body composition, and metabolic syndrome at 8 years.Journal of pediatric gastroenterology and nutrition · 2025Observational
- ObMetrics: A Shiny app to assist in metabolic syndrome assessment in paediatric obesity.Pediatric obesity · 2025Observational
- Ultra-processed food consumption and cardiometabolic risk in Canada: a cross-sectional analysis of the Canadian health measures survey.Nutrition & metabolism · 2025Article
- Article
- The Role of SHBG as a Marker in Male Patients with Metabolic-Associated Fatty Liver Disease: Insights into Metabolic and Hormonal Status.Journal of clinical medicine · 2024Article
- Untangling pathways of risk factors associated with hypertension among dysglycemia adults in eastern China: a structural equation model approach.Acta diabetologica · 2024Article
- Review
- Assessing the Relationship between Systemic Immune-Inflammation Index and Metabolic Syndrome in Children with Obesity.International journal of molecular sciences · 2023Article
- Exploratory Longitudinal Analysis of the Circulating CHIT1 Activity in Pediatric Patients with Obesity.Children (Basel, Switzerland) · 2023Article
- Components of the metabolic syndrome in girls with Turner syndrome treated with growth hormone in a long term prospective study.Frontiers in endocrinology · 2023Article
28 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo assess prevalence of the insulin resistance syndrome (IRS: obesity, abnormal glucose homoeostasis, dyslipidaemia, and hypertension) in obese UK children and adolescents of different ethnicities and to assess whether fasting data is sufficient to identify IRS in childhood obesity.
methodsA total of 103 obese (BMI >95th centile) children and adolescents 2-18 years of age referred for assessment underwent an oral glucose tolerance test, measurement of fasting lipids, and blood pressure determination. Main outcome measures were prevalence of components of IRS by modified WHO criteria, with IRS defined as > or =3 components (including obesity).
resultsThere were 67 girls (65%). BMI z-score ranged from 1.65 to 6.15, with 72% having a z-score > or =3.0. Abnormal glucose homoeostasis was identified in 46% (hyperinsulinism in 40%, impaired fasting glucose in 0.8%, impaired glucose tolerance in 11%). No subjects had silent type 2 diabetes. Dyslipidaemia was identified in 30% and hypertension in 32%. Thirty one per cent had obesity alone, 36% had two components, 28% had three, and 5% had all four components. Birth weight, BMI, and family history of IRS were not associated with risk of IRS. Higher age increased the risk of IRS; however the syndrome was seen in 30% of children under 12 years. The use of fasting glucose and insulin data for identifying IRS had a sensitivity of 88% and specificity of 100%.
conclusionsOne third of obese children and adolescents have the IRS; however type 2 diabetes is rare. Obese children with the IRS may form a high risk group to whom scarce intervention resources should be targeted. Further work is needed to develop appropriate screening programmes for IRS components in significantly obese children.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.