ArticleJournal of virology2005
Suppression of RNA silencing by a geminivirus nuclear protein, AC2, correlates with transactivation of host genes.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
106 citing papers in PubMed, 295 citations in OpenAlex.
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- In silico structural and disorder prediction of the tomato yellow leaf curl virus C2 protein and experimental assessment of subcellular localization and HR-like response.Journal of computer-aided molecular design · 2026Article
- Evaluation of CRISPR/Cas9 based single and multiplex gRNAs against ChiLCV in tobacco.Journal, genetic engineering & biotechnology · 2026Article
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- Transient expression analysis of promoters of okra enation leaf curl virus in Nicotiana benthamiana, cotton and okra plants.Virus genes · 2024Article
- Predicting candidate miRNAs for targeting begomovirus to induce sequence-specific gene silencing in chilli plants.Frontiers in plant science · 2024Article
- Differential expression of the genes encoding immune system components in response to3 Biotech · 2024Article
- The Past, Present, and Future of Wheat Dwarf Virus Management-A Review.Plants (Basel, Switzerland) · 2023Review
- A selective autophagy receptor VISP1 induces symptom recovery by targeting viral silencing suppressors.Nature communications · 2023Article
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- Combinatorial interactions between viral proteins expand the potential functional landscape of the tomato yellow leaf curl virus proteome.PLoS pathogens · 2022Article
- DNA methylation dynamics in response to abiotic and pathogen stress in plants.Plant cell reports · 2022Review
- Insights into the multifunctional roles of geminivirus-encoded proteins in pathogenesis.Archives of virology · 2022Review
- Influence of virus-host interactions on plant response to abiotic stress.Plant cell reports · 2021Review
- Interaction between βC1 of satellite and coat protein of Chili leaf curl virus plays a crucial role in suppression of host RNA silencing.Applied microbiology and biotechnology · 2021Article
- Population diversity of cassava mosaic begomoviruses increases over the course of serial vegetative propagation.The Journal of general virology · 2021Article
- Sub-cellular localization of suppressor proteins of tomato leaf curl New Delhi virus.Virusdisease · 2021Article
- Geminiviral Triggers and Suppressors of Plant Antiviral Immunity.Microorganisms · 2021Review
- Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bipartite geminiviruses encode a small protein, AC2, that functions as a transactivator of viral transcription and a suppressor of RNA silencing. A relationship between these two functions had not been investigated before. We characterized both of these functions for AC2 from Mungbean yellow mosaic virus-Vigna (MYMV). When transiently expressed in plant protoplasts, MYMV AC2 strongly transactivated the viral promoter; AC2 was detected in the nucleus, and a split nuclear localization signal (NLS) was mapped. In a model Nicotiana benthamiana plant, in which silencing can be triggered biolistically, AC2 reduced local silencing and prevented its systemic spread. Mutations in the AC2 NLS or Zn finger or deletion of its activator domain abolished both these effects, suggesting that suppression of silencing by AC2 requires transactivation of host suppressor(s). In line with this, in Arabidopsis protoplasts, MYMV AC2 or its homologue from African cassava mosaic geminivirus coactivated >30 components of the plant transcriptome, as detected with Affymetrix ATH1 GeneChips. Several corresponding promoters cloned from Arabidopsis were strongly induced by both AC2 proteins. These results suggest that silencing suppression and transcription activation by AC2 are functionally connected and that some of the AC2-inducible host genes discovered here may code for components of an endogenous network that controls silencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.