ArticleGenetics2005
A screen for genes that influence fibroblast growth factor signal transduction in Drosophila.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters.G3 (Bethesda, Md.) · 2021Article
- A Pair of Oviduct-Born Pickpocket Neurons Important for Egg-Laying in Drosophila melanogaster.Molecules and cells · 2016Article
- Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A Conserved Di-Basic Motif of Drosophila Crumbs Contributes to Efficient ER Export.Traffic (Copenhagen, Denmark) · 2015Article
- EGFR and FGFR pathways have distinct roles in Drosophila mushroom body development and ethanol-induced behavior.PloS one · 2014Article
- Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency.PLoS genetics · 2013Article
- Non-homogeneous combination of two porous genomes induces complex body shape trajectories in cyprinid hybrids.Frontiers in zoology · 2013Article
- A functional genome-wide in vivo screen identifies new regulators of signalling pathways during early Xenopus embryogenesis.PloS one · 2013Article
- Drosophila lilliputian is required for proneural gene expression in retinal development.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Tao kinases as coordinators of actin and microtubule dynamics in developing neurons.Communicative & integrative biology · 2011Article
- A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system.PLoS genetics · 2011Article
- Trafficking through COPII stabilises cell polarity and drives secretion during Drosophila epidermal differentiation.PloS one · 2010Article
- A screen for modifiers of notch signaling uncovers Amun, a protein with a critical role in sensory organ development.Genetics · 2009Article
- Synchronous and stochastic patterns of gene activation in the Drosophila embryo.Science (New York, N.Y.) · 2009Article
- Article
- Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling.Development (Cambridge, England) · 2009Article
- A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wing.Genetics · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The misexpression of an activated form of the FGF receptor (FGFR) Breathless in conjunction with downstream-of-FGF-receptor (Dof), an essential signaling molecule of the FGF pathway, in the Drosophila eye imaginal discs impairs eye development and results in a rough eye phenotype. We used this phenotype in a gain-of-function screen to search for modifiers of FGF signaling. We identified 50 EP stocks with insertions defining at least 35 genes that affect the rough eye phenotype. Among these genes, 4 appear to be specific for FGFR signaling, but most of the genes also influence other signaling pathways, as assessed by their effects on rough eyes induced by other activated receptor tyrosine kinases (RTKs). Analysis of loss-of-function alleles of a number of these genes in embryos indicates that in many cases the products are provided maternally and are involved in germ cell development. At least two of the genes, sar1 and robo2, show a genetic interaction with a hypomorphic dof allele, suggesting that they participate in FGF-mediated morphogenetic events during embryogenesis.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.