ReviewJournal of neural transmission (Vienna, Austria : 1996)2005
Transcription factor AP-2 and monoaminergic functions in the central nervous system.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Genetic polymorphisms and their association with neurobiological and psychological factors in anorexia nervosa: a systematic review.Frontiers in psychology · 2024Pooled it
- Dysfunction of Small-Conductance CaCells · 2024Article
- Somatic Cell Reprogramming for Nervous System Diseases: Techniques, Mechanisms, Potential Applications, and Challenges.Brain sciences · 2023Review
- The regulatory role of AP-2β in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential.Cell & bioscience · 2022Review
- 90 years of monoamine oxidase: some progress and some confusion.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Brain-specific HIV Nef identified in multiple patients with neurological disease.Journal of neurovirology · 2018Article
- Influence ofBrain and behavior · 2017Article
- Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders.Iranian journal of reproductive medicine · 2015Article
- Transcription Factor Activating Protein-2β (TFAP-2β) genotype and symptoms of attention deficit hyperactivity disorder in relation to symptoms of depression in two independent samples.European child & adolescent psychiatry · 2014Article
- Transcriptional regulation and its misregulation in Alzheimer's disease.Molecular brain · 2013Review
- Variants of SLC6A4 in depression risk following severe TBI.Brain injury · 2013Article
- AP-2β regulates amyloid beta-protein stimulation of apolipoprotein E transcription in astrocytes.Brain research · 2012Article
- Does the transcription factor AP-2beta have an impact on the genetic and early environmental influence on ethanol consumption?Journal of neural transmission (Vienna, Austria : 1996) · 2010Article
- Article
- Transcription factor AP-2 beta genotype and psychosocial adversity in relation to adolescent depressive symptomatology.Journal of neural transmission (Vienna, Austria : 1996) · 2009Article
- TFAP2A mutations result in branchio-oculo-facial syndrome.American journal of human genetics · 2008Article
- Computational selection and prioritization of candidate genes for fetal alcohol syndrome.BMC genomics · 2007Article
- Monoamine oxidases: activities, genotypes and the shaping of behaviour.Journal of neural transmission (Vienna, Austria : 1996) · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the central nervous system, transcription factor AP-2 family is one of the critical regulatory factors for neural gene expression and neuronal development. Several genes in the monoaminergic systems display AP-2 binding sites in regulatory regions. In addition, brainstem levels of transcription factor AP-2alpha and AP-2beta are positively correlated to monoamine measures in rat forebrain, suggesting a regulatory role of AP-2 also in the adult brain. Great changes in psychiatric phenotypes due to genetic factors are seldom the result of a single gene polymorphism. Recently, identification of combinations of candidate genes that are all linked to one disease or psychiatric phenotype has been discussed. The expression of these candidate genes might be regulated by the same transcription factors, e.g. AP-2. Recent data on transcription factor AP-2 family in relation to monoaminergic functions are described in this paper. Transcription factor AP-2beta genotype has been studied in relation to personality, platelet monoamine oxidase (MAO) activity, CSF-levels of monoamine metabolites, binge-eating disorder, premenstrual dysphoric disorder, and schizophrenia. Furthermore, the involvement of AP-2 in the molecular mechanism of antidepressant drugs is discussed. Altogether, this paper discusses data supporting a notion that the transcription factor AP-2 family is involved in the regulation of the monoaminergic systems both pre- and postnatally, and, therefore, might be involved in the pathophysiology of neuropsychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.