Evidence map›Paper›PMID 16014401›Full record

ReviewThe Journal of clinical endocrinology and metabolism2005

Cardiovascular autonomic neuropathy due to diabetes mellitus: clinical manifestations, consequences, and treatment.

Raelene E Maser, M James Lenhard

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in The Journal of clinical endocrinology and metabolism, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 76 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06461377 phase4recruitingstarted 2024, after this paper: background citation

The Ameliorative Effects of GLP-1RA on Diabetic Cardiac Autonomatic Neuropathy

Ran2024Enrolled50Registered outcomes20Posted comparisons0ConditionsDiabetes With Diabetic Autonomic Neuropathy (Diagnosis), Type 2 DiabetesArmsGlucagon-like peptide-1 receptor agonist：Semaglutide
PMID 24567799PMID 25685280PMID 26254961PMID 31552598PMID 32497872PMID 33292149PMID 33804063PMID 34317590PMID 34793438PMID 37021204PMID 37397902PMID 12716821other papers from this trial
Open the trial in the graph
NCT07558863 phase4recruitingstarted 2026, after this paper: background citation

A Study on the Effect of GLP-1 Receptor Agonist (GLP-1RA) Intervention on Cardiac Autonomic Neuropathy in Patients With Type 2 Diabetes Mellitus

Ran2026Enrolled60Registered outcomes6Posted comparisons0ConditionsDiabetes With Diabetic Autonomic Neuropathy (Diagnosis), Type 2 DiabetesArmsGLP-1 Receptor Agonists
PMID 26254961PMID 37021204PMID 34793438PMID 34317590PMID 33804063PMID 33292149PMID 32497872PMID 31552598PMID 37397902PMID 25685280PMID 24567799PMID 20460434other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 227 citations in OpenAlex.

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  4. The hemodynamic and pain impact of peripheral nerve block versus spinal anesthesia in diabetic patients undergoing diabetic foot surgery.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Raelene E MaserDepartment of Medical Technology, 305F Willard Hall Education Building, University of Delaware, Newark, Delaware 19716, USA. rmaser@UDEL.EDU
M James Lenhard
Christiana Care Health System · USUniversity of Delaware · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextThe aim of this article was to review the importance of the clinical identification of persons with cardiovascular autonomic neuropathy (CAN) and discuss potential treatment interventions. EVIDENCE ACQUISITION: A MEDLINE search was conducted for articles published during the last 20 yr. In addition, subsequent references of retrieved articles were reviewed. Search strategies included using key terms such as CAN, heart rate variability, orthostatic hypotension, and diabetes mellitus. EVIDENCE SYNTHESIS: CAN is a common form of diabetic autonomic neuropathy and causes abnormalities in heart rate control as well as central and peripheral vascular dynamics. The clinical manifestations of CAN include exercise intolerance, intraoperative cardiovascular lability, orthostatic hypotension, painless myocardial ischemia, and increased risk of mortality. CAN contributes to morbidity, mortality, and reduced quality of life for persons with diabetes. The American Diabetes Association has recently published a statement that provides guidelines for prevention, detection, and management of neuropathy, including CAN, for healthcare providers who care for patients with diabetes. Algorithms for the evaluation and treatment of the patient with CAN, even if the patient is asymptomatic, are provided in this review.

conclusionsOnce CAN is identified in a patient with diabetes, healthcare providers may consider altering the prescribed exercise regimen, increasing surveillance for cardiac ischemia, carefully reexamining the list of prescribed medications, and aggressively treating cardiovascular risk factors (e.g. hypertension) that may be associated with the development of CAN.

Indexed as

Autonomic Nervous System DiseasesCardiovascular AgentsCardiovascular DiseasesDiabetic NeuropathiesHumansCardiovascular Agents

Identifiers

PMID16014401
OpenAlexW2018364721

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.