ArticleNeurochemical research2005
Differentiation of neuroblastoma cell line N1E-115 involves several signaling cascades.
Article in Neurochemical research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 16 citations in OpenAlex.
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- Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization.Molecular & cellular proteomics : MCP · 2019Article
- Electrochemically reduced water protects neural cells from oxidative damage.Oxidative medicine and cellular longevity · 2014Article
- The perinucleolar compartment: RNA metabolism and cancer.Cancer treatment and research · 2013Article
- Improved genetically-encoded, FlincG-type fluorescent biosensors for neural cGMP imaging.Frontiers in molecular neuroscience · 2013Article
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7 authors at 1 institution in 1 country.
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Abstract
No systematic searches for differential expression of signaling proteins (SP) in undifferentiated vs. differentiated cell lineages were published and herein we used protein profiling for this purpose. The NIE-115 cell line was cultivated and an aliquot was differentiated with dimethylsulfoxide (DMSO), that is known to lead to a neuronal phenotype. Cell lysates were prepared, run on two-dimensional gel electrophoresis followed by MALDI-TOF-TOF identification of proteins and maps of identified SPs were generated. Seven SPs were comparable, 27 SPs: GTP-binding/Ras-related proteins, kinases, growth factors, calcium binding proteins, phosphatase-related proteins were observed in differentiated NIE-115 cells and eight SPs of the groups mentioned above were observed in undifferentiated cells only. Switching-on/off of several individual SPs from different signaling cascades during the differentiation process is a key to understand mechanisms involved. The findings reported herein are challenging in vitro and in vivo studies to confirm a functional role for deranged SPs.
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