ReviewStroke2005
Low-grade carotid stenosis: looking beyond the lumen with MRI.
Review in Stroke, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03507374 (PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis), which is not on this map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis
Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 198 citations in OpenAlex.
- Endarterectomy for symptomatic non-stenotic carotids: a systematic review and descriptive analysis.Stroke and vascular neurology · 2022Pooled it
- Carotid Artery Wall Imaging: Perspective and Guidelines from the ASNR Vessel Wall Imaging Study Group and Expert Consensus Recommendations of the American Society of Neuroradiology.AJNR. American journal of neuroradiology · 2018Guideline
- Added Value of 3D Proton-Density Weighted Images in Diagnosis of Intracranial Arterial Dissection.PloS one · 2016Trial
- Carotid atherosclerotic calcification does not result in high signal intensity in MR imaging of intraplaque hemorrhage.AJNR. American journal of neuroradiology · 2010Trial
- Clinically oriented deep learning framework for automated vessel wall segmentation in black-blood MRI: a multi-center study.European radiology · 2026Article
- Low-grade carotid artery stenosis is associated with progression of brain atrophy and cognitive decline. The SMART-MR study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Inverse material parameter estimation of patient-specific finite element models at the carotid bifurcation: The impact of excluding the zero-pressure configuration and residual stress.International journal for numerical methods in biomedical engineering · 2023Article
- B-mode ultrasound characteristics of carotid plaques in symptomatic and asymptomatic patients with low-grade stenosis.PloS one · 2023Article
- Ex Vivo Study Using Diffusion Tensor Imaging to Identify Biomarkers of Atherosclerotic Disease in Human Cadaveric Carotid Arteries.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- Increased Regional Market Competition is Associated with a Lower Threshold for Revascularization in Asymptomatic Carotid Artery Stenosis.Annals of vascular surgery · 2022Article
- Characterization of Restenosis following Carotid Endarterectomy Using Contrast-Enhanced Vessel Wall MR Imaging.AJNR. American journal of neuroradiology · 2022Article
- Impact Analysis of Different CT Configurations of Carotid Artery Plaque Calcifications on Cerebrovascular Events.AJNR. American journal of neuroradiology · 2022Article
- Carotid Intraplaque Hemorrhage and Stenosis: At What Stage of Plaque Progression Does Intraplaque Hemorrhage Occur, and When is It Most Likely to Be Associated with Symptoms?AJNR. American journal of neuroradiology · 2021Article
- Association between Periodontal Health and Stroke: Results from the 2013-2015 Korea National Health and Nutrition Examination Survey (KNHANES).Journal of dental sciences · 2021Article
- Perivascular Fat Density and Contrast Plaque Enhancement: Does a Correlation Exist?AJNR. American journal of neuroradiology · 2020Article
- Article
- Co-existing cerebrovascular atherosclerosis predicts subsequent vascular event: a multi-contrast cardiovascular magnetic resonance imaging study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Article
- Superficial Calcification With Rotund Shape Is Associated With Carotid Plaque Rupture: An Optical Coherence Tomography Study.Frontiers in neurology · 2020Article
- Subclinical Atherosclerosis Imaging in People Living with HIV.Journal of clinical medicine · 2019Review
- Ex Vivo Assessment of Various Histological Differentiation in Human Carotid Plaque with Near-infrared Spectroscopy Using Multiple Wavelengths.Neurologia medico-chirurgica · 2019Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeThe management of carotid atherosclerosis is well-established for symptomatic stenosis above 69%, but the optimal approach for managing lower degrees of narrowing remains uncertain. Because the risk of stroke increases with higher grades of stenosis, we are inclined to consider low-grade disease to be low risk. This approach, however, does not take into account other factors such as plaque size or composition. Plaque may progress to a substantial size before it demonstrates significant stenosis by angiography. We know that low-grade disease can result in cerebrovascular ischemic events, but predicting vulnerable lesions has not been possible by relying on stenosis alone. SUMMARY OF REVIEW: An understanding of the clinical behavior of plaque causing little to no narrowing is now possible with the advent of high-resolution black blood MRI, a modality that does not rely on luminal narrowing for detection.
conclusionsWe present the current understanding of the clinical implications of low-grade carotid stenosis with an example of the MRI assessment of high-risk carotid plaque causing minimal narrowing that highlights the importance of looking beyond the lumen.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.