ReviewClinical cardiology2005
High-sensitivity C-reactive protein as a risk assessment tool for cardiovascular disease.
Review in Clinical cardiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01410604 (Inflammatory Mediators in Obese Adolescents With Insulin Resistance Following Metformin Treatment), which is not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Inflammatory Mediators in Obese Adolescents With Insulin Resistance Following Metformin Treatment: Controlled Randomized Clinical Trial
Who cites it
25 citing papers in PubMed, 78 citations in OpenAlex.
- From acute diagnosis to longitudinal risk stratification: a paradigm shift in the clinical role of cardiac biomarkers.Frontiers in cardiovascular medicine · 2026Article
- The Prognostic Value of hsCRP in CVD/CKD Among East Asian Population: A Scoping Review.JACC. Asia · 2025Article
- Concordant and discordant roles of remnant cholesterol and hs-CRP in cardiovascular disease; gender stratified analysis.Lipids in health and disease · 2025Article
- C-Reactive Protein as a Marker of Inflammation in Children and Adolescents with Metabolic Syndrome: A Systematic Review and Meta-Analysis.Biomedicines · 2023Review
- Leptin Concentrations Determine the Association between High-Sensitivity C-Reactive Protein Levels and Body Mass Index in Prepubertal Children.Nutrients · 2023Article
- Case report: A proposed role for cardiopulmonary exercise testing in detecting cardiac dysfunction in asymptomatic at-risk adolescents.Frontiers in pediatrics · 2023Article
- Abnormal left ventricular systolic reserve function detected by treadmill exercise stress echocardiography in asymptomatic type 2 diabetes.Frontiers in cardiovascular medicine · 2023Article
- Association between maternal gestational diabetes mellitus and high-sensitivity C-reactive protein levels in 8-year-old children: The Yamanashi Adjunct Study of the Japan Environment and Children's Study (JECS).Journal of diabetes investigation · 2022Article
- Sex-dependent relationship of C-reactive protein levels with HDL-cholesterol and HDL-phospholipid concentrations in children.Scientific reports · 2022Article
- Influence of Diet and Levels of Zonulin, Lipopolysaccharide and C-Reactive Protein on Cardiometabolic Risk Factors in Young Subjects.Nutrients · 2021Article
- Fluorescence Based on Surface Plasmon Coupled Emission for Ultrahigh Sensitivity Immunoassay of Cardiac Troponin I.Biomedicines · 2021Article
- Effect of welding fumes on the cardiovascular system: a six-year longitudinal study.Scandinavian journal of work, environment & health · 2021Article
- A Control-Theoretic Model of Atherosclerosis.International journal of molecular sciences · 2019Article
- Accelerated vascular aging and persistent cognitive impairment in older female breast cancer survivors.GeroScience · 2018Article
- Vegetable and Fruit Intakes Are Associated with hs-CRP Levels in Pre-Pubertal Girls.Nutrients · 2017Article
- Relationship between the extent of dissection and platelet activation in acute aortic dissection.Journal of cardiothoracic surgery · 2015Article
- Study of Serum Hepcidin as a Potential Mediator of the Disrupted Iron Metabolism in Obese Adolescents.International journal of health sciences · 2015Article
- Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Harsh parenting and adolescent health: a longitudinal analysis with genetic moderation.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2014Article
- C-reactive protein: clinical and epidemiological perspectives.Cardiology research and practice · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Almost half of first cardiovascular events occur in individuals with no known risk factors. Attempts in the last decade to predict cardiovascular risk more accurately have led to the emergence of a novel risk factor, C-reactive protein (CRP), which has proved to be as good a risk predictor as low-density lipoprotein cholesterol. C-reactive protein is an index of inflammation that is now believed to promote directly all stages of atherosclerosis, including plaque rupture. As measured by high-sensitivity assays, high-sensitivity CRP (hs-CRP) also independently predicts recurrent events in patients with known coronary artery diseases. Recent evidence implicates hs-CRP, and thus inflammation, in the metabolic syndrome and diabetes mellitus, particularly in women. As a clinical tool for cardiovascular risk assessment, hs-CRP testing enhances information provided by lipid screening or global risk assessment. Statin therapy and other interventions can lower hs-CRP. Whether or not such reductions can prevent cardiovascular events is under investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.