ArticleMolecular and cellular biology2005
Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Trial
- Transcriptional Regulators in the Cerebellum in Chronic Schizophrenia: Novel Possible Targets for Pharmacological Interventions.International journal of molecular sciences · 2025Article
- Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation.ACS synthetic biology · 2022Article
- New developments implicating IL-21 in autoimmune disease.Journal of autoimmunity · 2021Review
- HIV-1 infection and the lack of viral control are associated with greater expression of interleukin-21 receptor on CD8+ T cells.AIDS (London, England) · 2021Article
- IL-21 in Homeostasis of Resident Memory and Exhausted CD8 T Cells during Persistent Infection.International journal of molecular sciences · 2020Review
- Fueling Cancer Immunotherapy With Common Gamma Chain Cytokines.Frontiers in immunology · 2019Review
- The Common Cytokine Receptor γ Chain Family of Cytokines.Cold Spring Harbor perspectives in biology · 2018Review
- Increased Binding of Specificity Protein 1 to theFrontiers in immunology · 2018Article
- Article
- Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM.Human molecular genetics · 2014Article
- Th17 cells in autoimmune and infectious diseases.International journal of inflammation · 2014Review
- Cooperation of adenosine with macrophage Toll-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of PFKFB3 gene.The Journal of biological chemistry · 2011Article
- Interleukin-21 and cellular activation concurrently induce potent cytotoxic function and promote antiviral activity in human CD8 T cells.Human immunology · 2011Article
- Inflammatory cytokines in systemic lupus erythematosus.Journal of biomedicine & biotechnology · 2011Review
- Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Transcriptional activation of the interleukin-21 gene and its receptor gene by human T-cell leukemia virus type 1 Tax in human T-cells.The Journal of biological chemistry · 2009Article
- Sp1 phosphorylation and its regulation of gene transcription.Molecular and cellular biology · 2009Review
- Interleukin 21: a cytokine/cytokine receptor system that has come of age.Journal of leukocyte biology · 2008Review
- The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer.Current opinion in immunology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Interleukin-21 (IL-21) plays important roles in regulating the immune response. IL-21 receptor (IL-21R) mRNA is expressed at a low level in human resting T cells but is rapidly induced by mitogenic stimulation. We now investigate the basis for IL21R gene regulation in T cells. We found that the -80 to -20 region critically regulates IL-21R promoter activity and corresponds to a major DNase I-hypersensitive site. Electrophoretic mobility shift assays, DNA affinity chromatography followed by mass spectrometry, and chromatin immunoprecipitation assays revealed that Sp1 binds to this region in vitro and in vivo. Moreover, mutation of the Sp1 motif markedly reduced IL-21R promoter activity, and Sp1 small interfering RNAs effectively diminished IL-21R expression in activated T cells. Interestingly, upon T-cell receptor (TCR) stimulation, T cells increased IL-21R expression and Sp1 protein levels while decreasing Sp1 phosphorylation. Moreover, phosphatase inhibitors that increased phosphorylation of Sp1 diminished IL-21R transcription. These data indicate that TCR-induced IL-21R expression is driven by TCR-mediated augmentation of Sp1 protein levels and may partly depend on the dephosphorylation of Sp1.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.