ReviewInternational journal of cardiology2006
The novel role of C-reactive protein in cardiovascular disease: risk marker or pathogen.
Review in International journal of cardiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01334671 (The Clinical Effect of Intensive Statin Therapy in STEMI), which is not on this map. Cited by 68 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Clinical Effect of Intensive Statin Therapy in STEMI(ST-elevated Myocardial Infarction) Patients Before Emergency PCI(Percutaneous Coronary Intervention)
Open the trial in the graphWho cites it
68 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of normal weight obesity phenotype with inflammatory markers: A systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Breastfeeding and maternal cardiovascular risk factors and outcomes: A systematic review.PloS one · 2017Pooled it
- Impact of Obstructive Sleep Apnea Syndrome on Endothelial Function, Arterial Stiffening, and Serum Inflammatory Markers: An Updated Meta-analysis and Metaregression of 18 Studies.Journal of the American Heart Association · 2015Pooled it
- BARI 2D: A Reanalysis Focusing on Cardiovascular Events.Mayo Clinic proceedings · 2019Trial
- Improved blood biomarkers but no cognitive effects from 16 weeks of multivitamin supplementation in healthy older adults.Nutrients · 2015Trial
- Effect of exercise training modality on C-reactive protein in type 2 diabetes.Medicine and science in sports and exercise · 2012Trial
- The effects of strength and endurance training in patients with rheumatoid arthritis.Clinical rheumatology · 2011Trial
- Inflammation and exercise (INFLAME): study rationale, design, and methods.Contemporary clinical trials · 2008Trial
- Effects of the vasodilating beta-blocker nebivolol on smoking-induced endothelial dysfunction in young healthy volunteers.Vascular health and risk management · 2008Trial
- The effect of extended-release metoprolol succinate on C-reactive protein levels in persons with hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2006Trial
- Prognostic significance of the CALLY index for mortality among patients with cardiovascular-kidney-metabolic syndrome stages 0-3.Diabetology & metabolic syndrome · 2025Article
- Poly-epigenetic scores for cardiometabolic risk factors interact with demographic factors and health behaviors in older US Adults.Epigenetics · 2025Article
- The Role of C-Reactive Protein in Acute Myocardial Infarction: Unmasking Diagnostic, Prognostic, and Therapeutic Insights.Journal of clinical medicine · 2025Review
- Longitudinal associations in dementia family caregivers of ambivalent feelings and disruptive behaviors with C-reactive protein, interleukin-6, and D-dimer.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Article
- Impact of the environmental pollution on cardiovascular diseases: From epidemiological to molecular evidence.Heliyon · 2024Review
- Age-Related Association Between Circulating Inflammatory Indicators and Plaque Enhancement on High-Resolution Magnetic Resonance Imaging in Patients with Intracranial Atherosclerotic Stenosis.Journal of inflammation research · 2024Article
- Gender Differences and Amputation Risk in Peripheral Artery Disease-A Single-Center Experience.Diagnostics (Basel, Switzerland) · 2023Article
- Investigating the relationship between early life adversity, inflammation and alcohol use.Addiction biology · 2023Article
- Challenges and opportunities in rapid disaster research: lessons from the field in New Mexico and Vanuatu.Frontiers in sociology · 2023Article
- The relationship between serum C-reactive protein and senile hypertension.BMC cardiovascular disorders · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C-reactive protein (CRP) is a non-specific biomarker of inflammation. Recent research has shown that inflammation is an important step in the genesis of atherosclerosis, and is involved in the development of unstable plaques. Measurement of serum levels of CRP using a high sensitivity assay (hsCRP) can demonstrate subclinical inflammatory states, which may reflect vascular inflammation. Clinical studies have shown that elevated hsCRP levels in healthy populations predict vascular events such as myocardial infarction (MI) and stroke as well as the development of diabetes. In patients with acute coronary syndromes, higher hsCRP levels are associated with adverse outcomes and subsequent vascular events. There is data to suggest that aspirin, angiotensin converting enzyme (ACE) inhibitors and HMG Co-A reductase inhibitors (statins), which all reduce vascular event rates, also reduce serum levels of hsCRP and therefore hsCRP levels may potentially guide therapy. As well as having a critical role in risk prediction, recent evidence has emerged implicating CRP directly in atherogenesis. CRP has been found in human atherosclerotic plaque and CRP has been shown to cause endothelial cell dysfunction, oxidant stress and intimal hypertrophy in experimental models. We review the postulated roles of CRP in atherogenesis and prediction of vascular events, as well as discussing current recommendations for CRP testing in patients.
Indexed as
Identifiers
16337036What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.