ArticleAAPS PharmSciTech2005
Formulation and evaluation of mucoadhesive glipizide microspheres.
Article in AAPS PharmSciTech, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Development of a mucoadhesive drug delivery system and its interaction with gastric cells.Beilstein journal of nanotechnology · 2025Article
- Amphiphilic, lauric acid-coupled pluronic-based nano-micellar system for efficient glipizide delivery.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Utilization of a nanostructured lipid carrier encapsulating pitavastatin-Drug delivery · 2023Article
- Article
- Palmitic Acid-Pluronic F127-Palmitic Acid Pentablock Copolymer as a Novel Nanocarrier for Oral Delivery of Glipizide.Turkish journal of pharmaceutical sciences · 2019Article
- Preparation, Optimization and In vitro Evaluation of Glipizide Nanoparticles Integrated with Eudragit RS-100.Pharmaceutical nanotechnology · 2019Article
- Development and optimization of novel controlled-release pioglitazone provesicular powders using 3² factorial design.Drug delivery and translational research · 2015Article
- Formulation and evaluation of controlled-release of telmisartan microspheres: In vitro/in vivo study.Journal of food and drug analysis · 2014Article
- Development and optimization of enteric coated mucoadhesive microspheres of duloxetine hydrochloride using 3(2) full factorial design.International journal of pharmaceutical investigation · 2013Article
- Microencapsulation Approach for Orally Extended Delivery of Glipizide: In vitro and in vivo Evaluation.Indian journal of pharmaceutical sciences · 2012Article
- Preparation and in vitro Characterization of Porous Carrier-Based Glipizide Floating Microspheres for Gastric Delivery.Journal of young pharmacists : JYP · 2011Article
- Developing micro-/nanoparticulate drug delivery systems using "design of experiments".International journal of pharmaceutical investigation · 2011Article
- Improved bioavailability through floating microspheres of lovastatin.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2011Article
- Production and Evaluation of Chitosan from Aspergillus Niger MTCC Strains.Iranian journal of pharmaceutical research : IJPR · 2011Article
- Influence of rheology of dispersion media in the preparation of polymeric microspheres through emulsification method.AAPS PharmSciTech · 2009Article
- Formulation and optimization of solid lipid nanoparticle formulation for pulmonary delivery of budesonide using Taguchi and Box-Behnken design.Research in pharmaceutical sciencesArticle
- Development of floating chitosan-xanthan beads for oral controlled release of glipizide.International journal of pharmaceutical investigationArticle
- Preparation, characterization and optimization of glipizide controlled release nanoparticles.Research in pharmaceutical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this research was to formulate and systematically evaluate in vitro and in vivo performances of mucoadhesive microspheres of glipizide. Glipizide microspheres containing chitosan were prepared by simple emulsification phase separation technique using glutaraldehyde as a cross-linking agent. Results of preliminary trials indicate that volume of cross-linking agent, time for cross-linking, polymer-to-drug ratio, and speed of rotation affected characteristics of microspheres. Microspheres were discrete, spherical, and free flowing. The microspheres exhibited good mucoadhesive property in the in vitro wash-off test and also showed a high percentage drug entrapment efficiency. A 3(2) full factorial design was employed to study the effect of independent variables, polymer-to-drug ratio (X(1) ), and stirring speed (X(2) ) on dependent variables percentage mucoadhesion, t(80), drug entrapment efficiency, and swelling index. The best batch exhibited a high drug entrapment efficiency of 75% and a swelling index of 1.42; percentage mucoadhesion after 1 hour was 78%. The drug release was also sustained for more than 12 hours. The polymer-to-drug ratio had a more significant effect on the dependent variables. In vivo testing of the mucoadhesive microspheres to albino Wistar rats demonstrated significant hypoglycemic effect of glipizide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.