ArticleThe Journal of pediatrics2006
Longitudinal changes in insulin sensitivity, insulin secretion, and beta-cell function during puberty.
Article in The Journal of pediatrics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 3 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2017 · on this mapGuideline
- Low glycaemic index dietary interventions in youth with cystic fibrosis: a systematic review and discussion of the clinical implications.Nutrients · 2012Pooled it
- Prevention and treatment of pediatric obesity: an endocrine society clinical practice guideline based on expert opinion.The Journal of clinical endocrinology and metabolism · 2008Guideline
- Two-Year Treatment With Metformin During Puberty Does Not Preserve β-Cell Function in Youth With Obesity.The Journal of clinical endocrinology and metabolism · 2021Trial
- Exercise effects on arterial stiffness and heart health in children with excess weight: The SMART RCT.International journal of obesity (2005) · 2020Trial
- Body Weight and Insulin Resistance Indicators Among Children.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Gut microbiota and metabolic disease risk in youth.Cell reports. Medicine · 2026Review
- Youth-Onset Type 2 Diabetes: What We've Learned From Key Youth-Onset Type 2 Diabetes Studies, What We Still Don't Know, and Why It Is Important.Diabetes care · 2025Review
- Postprandial Glucose Turnover Differs Between Adolescents and Adults With Type 1 Diabetes: Triple Tracer Mixed Meal Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Pathophysiology and Treatment of Prediabetes and Type 2 Diabetes in Youth.Diabetes care · 2024Review
- Long-term tracking of glycosylated hemoglobin levels across the lifespan in type 1 diabetes: from infants to young adults.Annals of pediatric endocrinology & metabolism · 2024Article
- Childhood sleep: physical, cognitive, and behavioral consequences and implications.World journal of pediatrics : WJP · 2024Review
- Pubertal timing: A life course pathway linking early life risk to adulthood cardiometabolic health.PloS one · 2024Article
- Adolescent Diet Quality, Cardiometabolic Risk, and Adiposity: A Prospective Cohort.Journal of nutrition education and behavior · 2023Observational
- Trends in HOMA-IR values among South Korean adolescents from 2007-2010 to 2019-2020: a sex-, age-, and weight status-specific analysis.International journal of obesity (2005) · 2023Article
- Youth-Onset Type 2 Diabetes: The Epidemiology of an Awakening Epidemic.Diabetes care · 2023Review
- The threshold value for identifying insulin resistance (HOMA-IR) in an admixed adolescent population: A hyperglycemic clamp validated study.Archives of endocrinology and metabolism · 2023Article
- Persistence of β-Cell Responsiveness for Over Two Years in Autoantibody-Positive Children With Marked Metabolic Impairment at Screening.Diabetes care · 2022Article
- β Cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood.JCI insight · 2022Article
- Oral Glucose Tolerance Test Measures of First-phase Insulin Response and Their Predictive Ability for Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2022Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo determine longitudinal changes in insulin sensitivity (SI), insulin secretion, and beta-cell function during puberty in white and black youth. STUDY
designThe tolbutamide-modified frequently sampled intravenous glucose tolerance test and minimal modeling were used to measure SI, the acute insulin response to glucose (AIRg), and beta-cell function (disposition index, DI) in white (n = 46) and black (n = 46) children (mean [+/-SD] age at baseline = 10.2 +/- 1.7 years). Growth curve models (including 272 observations) with SI, AIRg, and DI regressed on Tanner stage were run after adjusting for covariates.
resultsAfter adjusting for covariates, growth curve models revealed that SI decreased and subsequently recovered by the end of puberty in whites and blacks (both p < .05), AIRg decreased linearly across Tanner stages in both races (both p < .001), and DI decreased across puberty in blacks (p = .001) but not in whites (p = .2).
conclusionsWhite and black youth exhibited transient insulin resistance and diminished AIRg during puberty. The progressive decline in DI among blacks versus whites may reflect a unique effect of puberty on beta-cell compensation in blacks. Future studies are needed to identify whether this difference contributes to the increased risk of type II diabetes in young blacks.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.