ArticleDifferentiation; research in biological diversity2006
A role for chromosomal protein HMGN1 in corneal maturation.
Article in Differentiation; research in biological diversity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 27 citations in OpenAlex.
- Chromatin structural gene expression stratifies cardiac cell populations in health and disease.Epigenetics · 2025Article
- Esophageal epithelial Ikkβ deletion promotes eosinophilic esophagitis in experimental allergy mouse model.The Journal of allergy and clinical immunology · 2025Article
- The miR-144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.Nature communications · 2024Article
- Biological Functions of HMGN Chromosomal Proteins.International journal of molecular sciences · 2020Review
- Review
- Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers.Genome research · 2015Article
- Spatiotemporally Regulated Ablation of Klf4 in Adult Mouse Corneal Epithelial Cells Results in Altered Epithelial Cell Identity and Disrupted Homeostasis.Investigative ophthalmology & visual science · 2015Article
- HMGB1 in health and disease.Molecular aspects of medicine · 2014Review
- Ocular surface development and gene expression.Journal of ophthalmology · 2013Article
- High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.The Journal of experimental medicine · 2012Article
- Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells.Developmental biology · 2011Article
- Regulation of corneal epithelial barrier function by Kruppel-like transcription factor 4.Investigative ophthalmology & visual science · 2011Article
- The nucleosome binding protein HMGN3 modulates the transcription profile of pancreatic beta cells and affects insulin secretion.Molecular and cellular biology · 2009Article
- Expression of nucleosomal protein HMGN1 in the cycling mouse hair follicle.Gene expression patterns : GEP · 2009Article
- Visualization of the expression of HMGN nucleosomal binding proteins in the developing mouse embryo and in adult mouse tissues.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Differential expression of the HMGN family of chromatin proteins during ocular development.Gene expression patterns : GEP · 2008Article
- Delineation of the protein module that anchors HMGN proteins to nucleosomes in the chromatin of living cells.Molecular and cellular biology · 2008Article
- HMGN1 modulates estrogen-mediated transcriptional activation through interactions with specific DNA-binding transcription factors.Molecular and cellular biology · 2007Article
- Basonuclin-null mutation impairs homeostasis and wound repair in mouse corneal epithelium.PloS one · 2007Article
- HMG chromosomal proteins in development and disease.Trends in cell biology · 2007Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Corneal differentiation and maturation are associated with major changes in the expression levels of numerous genes, including those coding for the chromatin-binding high-mobility group (HMG) proteins. Here we report that HMGN1, a nucleosome-binding protein that alters the structure and activity of chromatin, affects the development of the corneal epithelium in mice. The corneal epithelium of Hmgn1(-/-) mice is thin, has a reduced number of cells, is poorly stratified, is depleted of suprabasal wing cells, and its most superficial cell layer blisters. In mature Hmgn1(-/-)mice, the basal cells retain the ovoid shape of immature cells, and rest directly on the basal membrane which is disorganized. Gene expression was modified in Hmgn1(-/-) corneas: glutathione-S-transferase (GST)alpha 4 and GST omega 1, epithelial layer-specific markers, were selectively reduced while E-cadherin and alpha-, beta-, and gamma-catenin, components of adherens junctions, were increased. Immunofluorescence analysis reveals a complete co-localization of HMGN1 and p 63 in small clusters of basal corneal epithelial cells of wild-type mice, and an absence of p 63 expressing cells in the central region of the Hmgn1(-/-) cornea. We suggest that interaction of HMGN1 with chromatin modulates the fidelity of gene expression and affects corneal development and maturation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.