ArticleProceedings of the National Academy of Sciences of the United States of America2006
Alternatively spliced neuronal nitric oxide synthase mediates penile erection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Erectile Function and Sexual Behavior: A Review of the Role of Nitric Oxide in the Central Nervous System.Biomolecules · 2021Review
- Protein kinase A facilitates relaxation of mouse ileum via phosphorylation of neuronal nitric oxide synthase.British journal of pharmacology · 2020Article
- Urinary dysfunction in transgenic sickle cell mice: model of idiopathic overactive bladder syndrome.American journal of physiology. Renal physiology · 2019Article
- Akt phosphorylation of neuronal nitric oxide synthase regulates gastrointestinal motility in mouse ileum.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Normal increases in insulin-stimulated glucose uptake after ex vivo contraction in neuronal nitric oxide synthase mu (nNOSμ) knockout mice.Pflugers Archiv : European journal of physiology · 2019Article
- Article
- Alternative splicing and the evolution of phenotypic novelty.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy.Physiological reviews · 2016Review
- Mechanism of alternative splicing and its regulation.Biomedical reports · 2015Article
- Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Function of alternative splicing.Gene · 2013Review
- Preserved fertility despite erectile dysfunction in mice lacking the nitric oxide receptor.The Journal of physiology · 2013Article
- Cyclic AMP-dependent phosphorylation of neuronal nitric oxide synthase mediates penile erection.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Neuronal nitric oxide signaling regulates erection recovery after cavernous nerve injury.The Journal of urology · 2012Article
- Exercise training improves the defective centrally mediated erectile responses in rats with type I diabetes.The journal of sexual medicine · 2011Article
- Renal nitric oxide production in rat pregnancy: role of constitutive nitric oxide synthases.American journal of physiology. Renal physiology · 2010Article
- Salt-sensitive splice variant of nNOS expressed in the macula densa cells.American journal of physiology. Renal physiology · 2010Article
- The multiple actions of NO.Pflugers Archiv : European journal of physiology · 2010Review
- An insight into the sialome of Glossina morsitans morsitans.BMC genomics · 2010Article
- Expression of neuronal nitric oxide synthase splice variants in atherosclerotic plaques of apoE knockout mice.Atherosclerosis · 2009Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
A key role for nitric oxide (NO) in penile erection is well established, but the relative roles of the neuronal NO synthase (nNOS) versus endothelial forms of NOS are not clear. nNOS- and endothelial NOS-deficient mice maintain erectile function and reproductive capacity, questioning the importance of NO. Alternatively, residual NO produced by shorter transcripts in the nNOS(-/-) animals might suffice for normal physiologic function. We show that the beta splice variant of nNOS elicits normal erection despite a decrease in stimulus-response characteristics and a 5-fold increased sensitivity to the NOS inhibitor, l-NAME. Residual nNOSbeta generates only 10% of the normal NO level in vitro but produces citrulline and diaphorase staining reflecting in vivo NOS activity in pelvic ganglion nerves that is comparable to WT animals. Thus, alternatively spliced forms of nNOS are major mediators of penile erection and so may be targets for therapeutic intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.