ArticleJournal of virology1991
PEA1 and PEA3 enhancer elements are primary components of the polyomavirus late transcription initiator element.
Article in Journal of virology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Global Analysis of Mouse Polyomavirus Infection Reveals Dynamic Regulation of Viral and Host Gene Expression and Promiscuous Viral RNA Editing.PLoS pathogens · 2015Article
- Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells.Journal of virology · 2008Article
- Independent contributions of polyomavirus middle T and small T to the regulation of early and late gene expression and DNA replication.Journal of virology · 2006Article
- Inhibition of polyomavirus ori-dependent DNA replication by mSin3B.Journal of virology · 2002Article
- Role of middle T-small T in the lytic cycle of polyomavirus: control of the early-to-late transcriptional switch and viral DNA replication.Journal of virology · 2001Article
- Kinetic analysis of the steps of the polyomavirus lytic cycle.Journal of virology · 2001Article
- Natural biology of polyomavirus middle T antigen.Microbiology and molecular biology reviews : MMBR · 2001Review
- The host factor polyhedrin promoter binding protein (PPBP) is involved in transcription from the baculovirus polyhedrin gene promoter.Journal of virology · 1998Article
- Tiny T antigen: an autonomous polyomavirus T antigen amino-terminal domain.Journal of virology · 1997Article
- An enhancer of recombination in polyomavirus DNA.Journal of virology · 1996Article
- Characterization of two novel YY1 binding sites in the polyomavirus late promoter.Journal of virology · 1996Article
- The CAGT motif functions as an initiator element during early transcription of the baculovirus transregulator ie-1.Journal of virology · 1995Article
- Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals.The Journal of cell biology · 1995Article
- A novel transcriptional initiator activity of the GABP factor binding ets sequence repeat from the murine cytochrome c oxidase Vb gene.Gene expression · 1995Article
- Complex functional interactions at the early enhancer of the PQ strain of BK virus.Journal of virology · 1994Article
- Promoter activity of the proliferating-cell nuclear antigen gene is associated with inducible CRE-binding proteins in interleukin 2-stimulated T lymphocytes.Molecular and cellular biology · 1994Article
- Polyoma virus early-late switch: regulation of late RNA accumulation by DNA replication.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- The PU.1/Spi-1 proto-oncogene is a transcriptional regulator of a lentivirus promoter.Journal of virology · 1993Article
- Physical and functional characterization of transcriptional control elements in the equine infectious anemia virus promoter.Journal of virology · 1993Article
- Activation of the mouse proliferating cell nuclear antigen gene promoter by adenovirus type 12 E1A proteins.Japanese journal of cancer research : Gann · 1992Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The circular polyomavirus genome is transcribed from divergent promoter regions. Early mRNAs are initiated from a transcription complex formed at a TATA motif, the site of binding of transcription factor TFIID. Early transcription is promoted at a distance by the viral enhancer, which includes DNA motifs bound by cellular proteins of the PEA1 and PEA3 families of transcription activators. In contrast, the predominant viral late mRNAs are initiated within the viral enhancer, which lacks a TATA motif, near the PEA1 and PEA3 DNA motifs. Here, we demonstrate that these PEA1 and PEA3 binding sites are primary components of an autonomous transcription initiator element (Inr). They cause transcription of most polyomavirus late mRNAs and can direct the transcription of heterologous reporter genes. Alternative roles of these DNA motifs as activators of early mRNA transcription and as an initiator element for late mRNA transcription help explain how polyomavirus gene expression is regulated during lytic growth and provides a model for cellular transcription during development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.