ArticleRNA (New York, N.Y.)2006
Mechanism of ribosome shunting in Rice tungro bacilliform pararetrovirus.
Article in RNA (New York, N.Y.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The VP53 protein encoded by RNA2 of a fabavirus, broad bean wilt virus 2, is essential for viral systemic infection.Communications biology · 2024Article
- [The mechanisms of the translation of polymerase from HBV pregenomic RNA].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021Review
- Cell-free riboswitches.RSC chemical biology · 2021Review
- RNA-mediated translation regulation in viral genomes: computational advances in the recognition of sequences and structures.Briefings in bioinformatics · 2020Review
- Review
- Ribosome Shunting, Polycistronic Translation, and Evasion of Antiviral Defenses in Plant Pararetroviruses and Beyond.Frontiers in microbiology · 2018Review
- RNA based viral silencing suppression in plant pararetroviruses.Frontiers in plant science · 2015Review
- Evasion of short interfering RNA-directed antiviral silencing in Musa acuminata persistently infected with six distinct banana streak pararetroviruses.Journal of virology · 2014Article
- Further support of genetic conservation in Indian isolates of Rice tungro bacilliform virus by sequence analysis of an isolate from North-Western India.Virus genes · 2013Article
- Ribosomal protein S25 dependency reveals a common mechanism for diverse internal ribosome entry sites and ribosome shunting.Molecular and cellular biology · 2013Article
- Principles of translational control: an overview.Cold Spring Harbor perspectives in biology · 2012Review
- Review
- Non-canonical translation in RNA viruses.The Journal of general virology · 2012Review
- The large intergenic region of Rice tungro bacilliform virus evolved differentially among geographically distinguished isolates.Virus genes · 2012Article
- Short ORF-dependent ribosome shunting operates in an RNA picorna-like virus and a DNA pararetrovirus that cause rice tungro disease.PLoS pathogens · 2012Article
- RNA elements directing translation of the duck hepatitis B Virus polymerase via ribosomal shunting.Journal of virology · 2011Article
- Identification of potential conserved RNA secondary structure throughout influenza A coding regions.RNA (New York, N.Y.) · 2011Article
- Sucrose control of translation mediated by an upstream open reading frame-encoded peptide.Plant physiology · 2009Article
- Translation of cIAP2 mRNA is mediated exclusively by a stress-modulated ribosome shunt.Molecular and cellular biology · 2008Article
- Article
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5 authors.
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Abstract
In plant pararetroviruses, pregenomic RNA serves both as a template for replication through reverse transcription and a polysictronic mRNA. This RNA has a complex leader sequence preceding the first large ORF. The leader contains multiple short ORFs and strong secondary structure, both inhibiting ribosome scanning. Translation on this RNA is initiated by shunting, in which scanning ribosomes bypass a large portion of the leader with the inhibitory secondary structure and short ORFs. In Cauliflower mosaic virus (CaMV), the ribosome shunting mechanism involves translation of the 5'-proximal short ORF terminating in front of the secondary structure that appears to force ribosomes to take off and resume scanning at a landing site downstream of the structure. Using two plant protoplast systems and shunt-competent wheat-germ extracts, we demonstrate that in Rice tungro bacilliform virus (RTBV) shunting also depends on the first short ORF followed by strong secondary structure. Swapping of the conserved shunt elements between CaMV and RTBV revealed the importance of nucleotide composition of the landing sequence for efficient shunting. The results suggest that the mechanism of ribosome shunting is evolutionary conserved in plant pararetroviruses.
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