ArticleJournal of virology2006
Murine cytomegalovirus interference with antigen presentation contributes to the inability of CD8 T cells to control virus in the salivary gland.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- Mucosal T-cell responses to chronic viral infections: Implications for vaccine design.Cellular & molecular immunology · 2024Review
- Immune surveillance of cytomegalovirus in tissues.Cellular & molecular immunology · 2024Review
- Spatial kinetics and immune control of murine cytomegalovirus infection in the salivary glands.PLoS computational biology · 2024Article
- Indirect CD4Journal of virology · 2024Article
- Hematopoietic cell-mediated dissemination of murine cytomegalovirus is regulated by NK cells and immune evasion.PLoS pathogens · 2021Article
- Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8Frontiers in immunology · 2021Article
- Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A CD4Journal of virology · 2020Article
- Viral MHCI inhibition evades tissue-resident memory T cell formation and responses.The Journal of experimental medicine · 2019Article
- Murine cytomegalovirus degrades MHC class II to colonize the salivary glands.PLoS pathogens · 2018Article
- Niches for the Long-Term Maintenance of Tissue-Resident Memory T Cells.Frontiers in immunology · 2018Review
- Tissue-specific control of latent CMV reactivation by regulatory T cells.PLoS pathogens · 2017Article
- T cell responses to cytomegalovirus.Nature reviews. Immunology · 2016Review
- An MHC class I immune evasion gene of Marek׳s disease virus.Virology · 2015Article
- Murine cytomegalovirus immune evasion proteins operative in the MHC class I pathway of antigen processing and presentation: state of knowledge, revisions, and questions.Medical microbiology and immunology · 2012Review
- Absence of cross-presenting cells in the salivary gland and viral immune evasion confine cytomegalovirus immune control to effector CD4 T cells.PLoS pathogens · 2011Article
- B7-mediated costimulation of CD4 T cells constrains cytomegalovirus persistence.Journal of virology · 2011Article
- Immune evasion proteins of murine cytomegalovirus preferentially affect cell surface display of recently generated peptide presentation complexes.Journal of virology · 2010Article
- Immune evasion proteins enhance cytomegalovirus latency in the lungs.Journal of virology · 2009Article
- Structure and function of murine cytomegalovirus MHC-I-like molecules: how the virus turned the host defense to its advantage.Immunologic research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Compared to other organs, murine cytomegalovirus (MCMV) replication in the salivary gland is uniquely resistant to CD8 T-cell control. The contribution of viral genes that interfere with antigen presentation (VIPRs) to this resistance was assessed using a mutant lacking MCMV's known VIPRs. Salivary gland titers of the VIPR-deficient virus were at least 10-fold lower than those of the wild type during the persistent phase of infection; the defect was reversed by depleting CD8 T cells. Thus, VIPRs contribute to CD8 T cells' inability to control virus in the salivary gland.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.