ArticleThe Biochemical journal1991
Mechanisms of the stimulation of insulin release by oxytocin in normal mouse islets.
Article in The Biochemical journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
- [Decreased blood oxytocin levels in obesity and in patients with newly diagnosed type 2 diabetes].Problemy endokrinologii · 2026Article
- The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease.Endocrine reviews · 2025Review
- Article
- The Importance of Experimental Investigation of the Peripheral Oxytocin System.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Oxytocin: A Potential Therapeutic for Obesity.Journal of obesity & metabolic syndrome · 2021Review
- Oxytocin signal contributes to the adaptative growth of islets during gestation.Endocrine connections · 2021Article
- The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis.Journal of neuroendocrinology · 2020Review
- TheDiabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Oxytocin in metabolic homeostasis: implications for obesity and diabetes management.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019Review
- The dynamic plasticity of insulin production in β-cells.Molecular metabolism · 2017Review
- Coming full circle: contributions of central and peripheral oxytocin actions to energy balance.Endocrinology · 2013Review
- Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass.Aging · 2011Article
- Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Physiological concentrations of oxytocin powerfully stimulate insulin secretionin vitro.Endocrine · 1995Article
- Vasoactive intestinal polypeptide-augmented insulin release: actions on ionic fluxes and electrical activity of mouse islets.Diabetologia · 1993Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxytocin (OT) produced a dose-dependent increase in somatostatin, glucagon and insulin release by isolated mouse islets. A small effect on somatostatin release was observed with 0.1 nM-OT, but 1-10 nM-OT was required to affect A- and B- cells significantly. The effects of OT on somatostatin and glucagon release were similar in the presence of 3 mM- and 10 mM-glucose. No change in insulin release was produced by OT in 3 mM-glucose, but a stimulation was still observed in the presence of a maximally effective concentration of glucose (30 mM). The increase in insulin release produced by OT (in 15 mM-glucose) was accompanied by small accelerations of 86Rb and 45Ca efflux from islet cells. Omission of extracellular Ca2+ accentuated the effect of OT on 86Rb efflux, attenuated that on 45Ca efflux, and abolished that on release. OT never inhibited 86Rb efflux. It did not affect the resting potential of B-cells, but slightly increased the Ca2(+)-dependent electrical activity induced by 15 mM-glucose. OT did not affect cyclic AMP levels, but increased inositol phosphate levels in islet cells. It is suggested that the amplification of glucose-induced insulin release that OT produces is due to a stimulation of phosphoinositide metabolism, and presumably an activation of protein kinase C, rather than to a change in cyclic AMP levels or a direct action on the membrane potential. Since OT is present in the pancreas, it is possible that it exerts a neuropeptidergic control of the islet function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.