ArticleJournal of the American College of Cardiology2006
Family history of diabetes is a major determinant of endothelial function.
Article in Journal of the American College of Cardiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02633488 (Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Early Alterations in Glucose Homeostasis Associated with a Family History of Diabetes Mellitus: A Systematic Review and Meta-Analysis.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes.Atherosclerosis · 2009Trial
- The Association Between Subclinical Atherosclerosis Serum Markers and Oxidative DNA Damage in Normoglycemic Normotolerant Offspring of Diabetic Parents.Journal of diabetes · 2025Article
- Association of Paternal Diabetes With Hemorrhagic Stroke in Bangladeshi Women: The MAGPIE Study.Health science reports · 2025Article
- Association Between a First-Degree Family History and Self-Reported Personal History of Obesity, Diabetes, and Heart and Blood Conditions: Results From the All of Us Research Program.Journal of the American Heart Association · 2023Article
- Gut microbiota and obesity: New insights.Frontiers in nutrition · 2022Review
- A family history of type 2 diabetes as a predictor of fatty liver disease in diabetes-free individuals with excessive body weight.Scientific reports · 2021Article
- Association between a family history of diabetes and carotid artery atherosclerosis in Korean adults.Epidemiology and health · 2021Article
- Comparison of the effects of sibling and parental history of type 2 diabetes on metabolic syndrome.Scientific reports · 2020Article
- Association of familial history of diabetes or myocardial infarction and stroke with risk of cardiovascular diseases in four German cohorts.Scientific reports · 2020Article
- Glycaemic status during pregnancy and longitudinal measures of fetal growth in a multi-racial US population: a prospective cohort study.The lancet. Diabetes & endocrinology · 2020Article
- Metabolic flexibility is impaired in response to acute exercise in the young offspring of mothers with type 2 diabetes.Physiological reports · 2019Article
- Insulin Access to Skeletal Muscle is Preserved in Obesity Induced by Polyunsaturated Diet.Obesity (Silver Spring, Md.) · 2018Article
- Contribution of a first-degree family history of diabetes to increased serum adipocyte fatty acid binding protein levels independent of body fat content and distribution.International journal of obesity (2005) · 2016Article
- Elevation in fibroblast growth factor 23 and its value for identifying subclinical atherosclerosis in first-degree relatives of patients with diabetes.Scientific reports · 2016Article
- Insulin access to skeletal muscle is impaired during the early stages of diet-induced obesity.Obesity (Silver Spring, Md.) · 2016Article
- Influence of a family history of type 2 diabetes, demographic and clinical data on carotid intima-media thickness in patients with type 1 diabetes: a cross-sectional study.Cardiovascular diabetology · 2014Article
- A prospective single arm study of the effect of an acute oral glucose loading on the endothelial function of healthy participants.Journal of diabetes and metabolic disorders · 2014Article
- Gestational diabetes mellitus worsens the profile of cardiometabolic risk markers and decrease indexes of beta-cell function independently of insulin resistance in nondiabetic women with a parental history of type 2 diabetes.Journal of diabetes research · 2014Article
- Endothelium and its alterations in cardiovascular diseases: life style intervention.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesWe evaluated whether endothelial dysfunction was present in nondiabetic persons with a family history (FH) of diabetes and assessed its relationship with insulin resistance and atherosclerosis risk factors.
backgroundAtherosclerosis is frequently present when type 2 diabetes (T2D) is first diagnosed. Endothelial dysfunction contributes to atherogenesis.
methodsOral glucose tolerance and brachial artery flow-mediated, endothelium-dependent vasodilation (EDV) were assessed in 38 nondiabetic subjects; offspring of two parents with T2D (FH+) or with no first-degree relative with diabetes (FH-).
resultsAlthough fasting glucose was higher in FH+ than FH- (5.3 +/- 0.1 mmol/l vs. 4.9 +/- 0.1 mmol/l, p < 0.03), glycemic burden assessed as 2-h or area-under-the-curve glucose after glucose load or glycosylated hemoglobin (HbA1c), and measures of insulin sensitivity or inflammation did not differ. Brachial artery flow-mediated EDV was reduced in FH+ (7.1 +/- 0.9% vs. 11.7 +/- 1.6%, p < 0.02), with no difference in nitroglycerin-induced endothelium-independent vasodilatation. In the combined cohort, only FH+ (r2 = 0.12, p < 0.02) and HbA1c (r2 = 0.14, p < 0.02) correlated with EDV. Insulin resistance, assessed by tertile of homeostasis model assessment of insulin resistance (HOMA-IR), was associated with impaired endothelium-dependent vasodilatation in FH- (p < 0.03, analysis of variance), but not in FH+, as even the most insulin-sensitive FH+ offspring had diminished endothelial function. In multiple regression analysis, including established cardiac risk factors, blood pressure and lipids, HbA1c, and HOMA-IR, FH remained a significant determinant of EDV (p = 0.04).
conclusionsBioavailability of nitric oxide is lower in persons with a strong FH of T2D. Glycemic burden, even in the nondiabetic range, can contribute to endothelial dysfunction. Abnormalities of endothelial function may contribute to atherosclerosis before development of overt diabetes.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.