ArticleJournal of neuroscience methods2006
A multiplexed proteomics approach to differentiate neurite outgrowth patterns.
Article in Journal of neuroscience methods, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Proteomic analysis of novel targets associated with the enhancement of TrkA-induced SK-N-MC cancer cell death caused by NGF.Experimental & molecular medicine · 2016Article
- Master redox regulator Trx1 upregulates SMYD1 & modulates lysine methylation.Biochimica et biophysica acta · 2015Article
- Proteomic mechanisms of cardioprotection during mammalian hibernation in woodchucks, Marmota monax.Journal of proteome research · 2013Article
- A multidimensional approach to an in-depth proteomics analysis of transcriptional regulators in neuroblastoma cells.Journal of neuroscience methods · 2013Article
- Proteomic identification of immunoproteasome accumulation in formalin-fixed rodent spinal cords with experimental autoimmune encephalomyelitis.Journal of proteome research · 2012Article
- Type 1 equilibrative nucleoside transporter regulates ethanol drinking through accumbal N-methyl-D-aspartate receptor signaling.Biological psychiatry · 2011Article
- Neuroproteomics approaches to decipher neuronal regeneration and degeneration.Molecular & cellular proteomics : MCP · 2010Review
- iTRAQ-based shotgun neuroproteomics.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Quantitative Proteomic Analysis of Formalin Fixed Paraffin Embedded Oral HPV Lesions from HIV Patients.The open proteomics journal · 2008Article
- Identification of differentially expressed proteins in experimental autoimmune encephalomyelitis (EAE) by proteomic analysis of the spinal cord.Journal of proteome research · 2007Article
- Recent advances in neuroproteomics.Current opinion in molecular therapeutics · 2007Review
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
We report here a method for proteomics pattern discovery by utilizing a self-organizing map approach to analyze data obtained from a novel multiplex iTRAQ proteomics method. Through the application of this technique, we were able to delineate the early molecular events preceding dorsal root ganglia neurite outgrowth induced by either nerve growth factor (NGF) or an immunophilin ligand, JNJ460. Following pattern analysis we discovered that each neurotrophic agent promoted mostly distinct increases in protein expression with few overlapping patterns. In the NGF-treated group, proteins possessing "biosynthesis function" (p < 0.002) and "ribosome localization" (p < 0.0003) were increased, while proteins promoting "organogenesis" (p < 0.004) and related "signal transduction" (p < 0.008) functions were notably increased in the JNJ460-treated group. This study suggests that the properties of neurite outgrowth triggered by NGF and JNJ460 can be distinguished at the proteome level. Multiplexed proteomics analysis, along with pattern discovery bioinformatics tools, has the capability to differentiate subtle neuroproteomics patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.