ArticleMolecular and cellular biochemistry2006
Sodium chloride regulates Extracellular Regulated Kinase 1/2 in different tumor cell lines.
Article in Molecular and cellular biochemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Shiga Toxin Type 2 Aggravates G1/S Phase Cell Cycle Arrest, Mediating Caspase-Independent Cell Death under Hyperosmotic Conditions in the Kidney.Journal of microbiology and biotechnology · 2025Article
- High concentrations of NaCl induce cell swelling leading to senescence in human cells.Molecular and cellular biochemistry · 2016Article
- Multifactorial anticancer effects of digalloyl-resveratrol encompass apoptosis, cell-cycle arrest, and inhibition of lymphendothelial gap formation in vitro.British journal of cancer · 2010Article
- SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network.The EMBO journal · 2010Article
- Hypertonicity activates GSK3beta in tumor cells.Molecular and cellular biochemistry · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perturbations of the extracellular ionic content by different hypo- or hyperosmolar stimuli initiate stress responses to maintain cell viability that include activation of Mitogen Activated Protein Kinases (MAPK) in cell lines derived from kidney epithelium. When hyperosmolar conditions induced by different salts occurred in the extracellular environment of tumor-derived cell lines, they activated the Extracellular Regulated Kinase 1/2 by increasing its phosphorylation steady-state on Thr202/Tyr204 in a time- and dose-dependent manner. It was found that Extracellular Regulated Kinase 1/2 activation is a consequence of selective phosphorylation by mitogen-activated protein kinase/ERK kinase. Changes in cell shape or in tubulin or actin cytoskeletal structure were not found, although cell growth arrest was observed as well as induction of apoptosis and modified cell migration ability that were dependent upon Extracellular Regulated Kinase 1/2 activation evidencing a critical role for the Extracellular Regulated Kinase 1/2 in mediating survival of cells in hyperosmotic conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.