Evidence map›Paper›PMID 16936160›Full record

Trial reportDiabetes care2006

Effect of weight loss with lifestyle intervention on risk of diabetes.

Richard F Hamman, Rena R Wing, Sharon L Edelstein, John M Lachin, George A Bray, Linda Delahanty, Mary Hoskin, Andrea M Kriska, Elizabeth J Mayer-Davis, Xavier Pi-Sunyer and 3 more

5 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 614 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
614citing papers in PubMed, 16 pooled it
39.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06948825 phase2recruitingstarted 2025, after this paper: background citation

Effectiveness Study of a Lifestyle Intervention Versus Metformin in Mothers With Recent Gestational Diabetes

Ran2025Enrolled60Registered outcomes12Posted comparisons0ConditionsGestational Diabetes Mellitus in Pregnancy, Postpartum Care, Weight LossArmsEnhanced Lifestyle Intervention, Lifestyle Intervention, Metformin Hcl 850Mg Tab
PMID 26840133PMID 11832527PMID 12436333PMID 29683911PMID 28632867PMID 27654119PMID 26459420PMID 11333990PMID 11547793PMID 12545145PMID 15932841PMID 17596462other papers from this trial
Open the trial in the graph
NCT01004848 nacompletednot on this mapstarted 2009, after this paper: background citation

Collaborations for Health Improvement in East Harlem-Project HEED

TypeinterventionalSponsorIcahn School of Medicine at Mount SinaiRan2009 to 2012Enrolled402ConditionsPre-diabetesArmsPeer-Led Lifestyle Education on Weight Loss
NCT01803737 nacompletednot on this mapstarted 2013, after this paper: background citation

Feasibility of a Campaign Intervention Compared to a Standard Behavioral Weight Loss Intervention in Overweight and Obese Adults

TypeinterventionalSponsorUniversity of PittsburghRan2013 to 2013Enrolled26ConditionsWeight LossArmsStandard Behavioral Weight Loss Intervention (SBWL), Campaign Intervention (CI)
NCT03139019 nacompletednot on this mapstarted 2014, after this paper: background citation

Medicaid Incentives for the Prevention of Chronic Diseases: Diabetes Prevention

TypeinterventionalSponsorUniversity of PennsylvaniaRan2014 to 2016Enrolled596ConditionsDiabetes PreventionArmsProcess incentives, Outcome incentives, Process and Outcome incentives
NCT07079722 narecruitingnot on this mapstarted 2025, after this paper: background citation

Educational Program for Type 2 Diabetes Prevention With Integrated Physical Exercise: Digital and In-Person Approach

TypeinterventionalSponsorFaculdade de Motricidade HumanaRan2025 to 2026Enrolled90ConditionsPre-diabetesArmsExercise
3 · Its place in the literature

Who cites it

614 citing papers in PubMed, 16 syntheses or guidelines pooled it, 1,340 citations in OpenAlex.

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  8. Lower-Intensity Interventions for Prediabetes: A Systematic Review.American journal of preventive medicine · 2023
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  10. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Guideline
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554 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 1 country.

Richard F HammanDiabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Blvd., Suite 750, Rockville, MD 20852, USA. dppmail@biostat.bsc.gwu.edu
Rena R Wing
Sharon L Edelstein
John M Lachin
George A Bray
Linda Delahanty
Mary Hoskin
Andrea M Kriska
Elizabeth J Mayer-Davis
Xavier Pi-Sunyer
Judith Regensteiner
Beth Venditti
Judith Wylie-Rosett
George Washington University · USUniversity of Colorado Denver · USUniversity of Pittsburgh · USAlbert Einstein College of Medicine · USBrown University · USHarvard University Press · USNational Institute of Diabetes and Digestive and Kidney Diseases · USPennington Biomedical Research Center · USSt. Luke's Hospital · USUniversity of South Carolina · US

Funding

PRIMARY PREVENTION TRIAL--DATA COORDINATING CENTERU01DK048489 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI JABLONSKI, KATHLEEN ANN, TEMPROSA, MARINELLA · 1994 to 2021
$84.8M
NIDDK NIH HHS U01 DK048489
6 · The paper itself

Abstract

objectiveDiabetes Prevention Program (DPP) participants randomized to the intensive lifestyle intervention (ILS) had significantly reduced risk of diabetes compared with placebo participants. We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS participants. RESEARCH DESIGN AND

methodsFor this study, we analyzed one arm of a randomized trial using Cox proportional hazards regression over 3.2 years of follow-up.

resultsA total of 1,079 participants were aged 25-84 years (mean 50.6 years, BMI 33.9 kg/m(2)). Weight loss was the dominant predictor of reduced diabetes incidence (hazard ratio per 5-kg weight loss 0.42 [95% CI 0.35-0.51]; P < 0.0001). For every kilogram of weight loss, there was a 16% reduction in risk, adjusted for changes in diet and activity. Lower percent of calories from fat and increased physical activity predicted weight loss. Increased physical activity was important to help sustain weight loss. Among 495 participants not meeting the weight loss goal at year 1, those who achieved the physical activity goal had 44% lower diabetes incidence.

conclusionsInterventions to reduce diabetes risk should primarily target weight reduction.

Indexed as

Life StyleAdultAgedAged, 80 and overBody Mass IndexBody WeightDiabetes MellitusEnergy IntakeEnergy MetabolismFemaleFollow-Up StudiesHumansMaleMiddle AgedObesityRisk Factors

Identifiers

PMID16936160
PMCPMC1762038
OpenAlexW2114104256

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.