ArticleJournal of virology2006
Oligomerization of hantavirus nucleocapsid protein: analysis of the N-terminal coiled-coil domain.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Genomic characterization of LaoThe Journal of general virology · 2026Article
- Identification and characterization of codon usage pattern and influencing factors in HFRS-causing hantaviruses.Frontiers in immunology · 2023Article
- Comprehensive computational analysis reveals YXXΦ[I/L/M/F/V] motif and YXXΦ-like tetrapeptides across HFRS causing Hantaviruses and their association with viral pathogenesis and host immune regulation.Frontiers in immunology · 2022Article
- The nucleocapsid protein of hantaviruses: much more than a genome-wrapping protein.Virus genes · 2018Review
- The ClusPro web server for protein-protein docking.Nature protocols · 2017Article
- Complete genome of a Puumala virus strain from Central Europe.Virus genes · 2015Article
- Antigenic properties of N protein of hantavirus.Viruses · 2014Review
- Small interfering RNA inhibition of Andes virus replication.PloS one · 2014Article
- Article
- Identification of two functional domains within the arenavirus nucleoprotein.Journal of virology · 2011Article
- Characterization of two substrains of Puumala virus that show phenotypes that are different from each other and from the original strain.Journal of virology · 2011Article
- Oligomerization of Uukuniemi virus nucleocapsid protein.Virology journal · 2010Article
- Evolutionary insights from a genetically divergent hantavirus harbored by the European common mole (Talpa europaea).PloS one · 2009Article
- NMR structure of the N-terminal coiled coil domain of the Andes hantavirus nucleocapsid protein.The Journal of biological chemistry · 2008Article
- New Genetic Lineage of Tula Hantavirus in Microtus arvalis obscurus in Eastern Kazakhstan.The open virology journal · 2008Article
- Thottapalayam virus is genetically distant to the rodent-borne hantaviruses, consistent with its isolation from the Asian house shrew (Suncus murinus).Virology journal · 2007Article
- The coiled-coil domain structure of the Sin Nombre virus nucleocapsid protein.Journal of molecular biology · 2007Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hantaviruses constitute a genus in the family Bunyaviridae. They are enveloped negative-strand RNA viruses with a tripartite genome encoding the nucleocapsid (N) protein, the two surface glycoproteins Gn and Gc, and an RNA-dependent RNA polymerase. The N protein is the most abundant component of the virion; it encapsidates genomic RNA segments forming ribonucleoproteins and participates in genome transcription and replication as well as virus assembly. In the course of RNA encapsidation, N protein forms intermediate trimers via head-to-head and tail-to-tail interactions. We analyzed the amino-terminal trimerization domain (amino acid residues 1 to 77) of Tula hantavirus using computer modeling, mammalian two-hybrid assay, and immunofluorescence assay. The results obtained were consistent with the existence of an antiparallel coiled-coil stabilized by interactions between hydrophobic residues. Residues L44, V51, and L58 were important for the N-N interaction; other residues, e.g., L25 and V32, also made a contribution, albeit a modest one. Our alignments of the N-terminal domain of the hantaviral N proteins suggest the coiled-coil structure, and hence the mode of N-protein oligomerization, is conserved among hantaviruses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.