Evidence map›Paper›PMID 16949375›Full record

ArticleThe American journal of cardiology2006

Epidemiology and prognostic implications of contrast-induced nephropathy.

Peter A McCullough, Andy Adam, Christoph R Becker, Charles Davidson, Norbert Lameire, Fulvio Stacul, James Tumlin, CIN Consensus Working Panel

Registry-linked trialAbstract readConsensus Statement
PubMed Publisher
In one paragraph

Article in The American journal of cardiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04375787 (High Dose Atorvastatin Raises Threshold of Contrast Induced Nephropathy in Diabetic Patients Undergoing Elective Coronary Intervention), which is not on this map. Cited by 132 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 9 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04375787 phase4completedstarted 2020, after this paper: background citation

High Dose Atorvastatin Raises Threshold of Contrast Induced Nephropathy in Diabetic Patients Undergoing Elective Coronary Intervention

Ran2020Enrolled200Registered outcomes1Posted comparisons0ConditionsCoronary DiseaseArmsAtorvastatin
PMID 22714555PMID 24696755PMID 21943940other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 9 syntheses or guidelines pooled it, 432 citations in OpenAlex.

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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Peter A McCulloughWilliam Beaumont Hospital, Royal Oak, Michigan 48073, USA. pmccullough@beaumont.edu
Andy Adam
Christoph R Becker
Charles Davidson
Norbert Lameire
Fulvio Stacul
James Tumlin
CIN Consensus Working Panel
Beaumont Hospital · USGhent University Hospital · BENorthwestern Memorial Hospital · USRenal Research Institute · USSt Thomas' Hospital · GBUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contrast-induced nephropathy (CIN), usually defined as an increase in serum creatinine of 0.5 mg/dL (44.2 mumol/L), or a 25% increase from the baseline value 48 hours after the procedure, is a common and potentially serious complication of the use of iodinated contrast media in patients at risk of acute renal injury. It is an important cause of hospital-acquired renal failure, responsible for approximately 11% of cases. CIN may be difficult to distinguish from cholesterol embolization, another cause of postprocedure renal impairment. The reported incidence of CIN varies depending on the patient population studied. The impact of postprocedural renal impairment on clinical outcomes has been evaluated most extensively in patients undergoing percutaneous coronary intervention. CIN is associated with increased mortality both in hospital and at 1 year. A higher incidence of in-hospital and late cardiovascular events, as well as longer hospital stays, has been reported in patients developing CIN. In a small proportion of patients, CIN is severe enough to require dialysis, and these patients have a particularly poor prognosis. Many of the risk markers for CIN are also predictive of a worse prognosis.

Indexed as

Acute Kidney InjuryContrast MediaCreatinineDiagnosis, DifferentialEmbolism, CholesterolHumansIncidencePrognosisRenal DialysisRisk FactorsContrast MediaCreatinine

Identifiers

PMID16949375
OpenAlexW2037354898

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.