Evidence map›Paper›PMID 16971976›Full record

GuidelineThe Canadian journal of cardiology2006

Canadian Cardiovascular Society position statement--recommendations for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease.

Ruth McPherson, Jiri Frohlich, George Fodor, Jacques Genest, Canadian Cardiovascular Society

Erratum issued Registry-linked trialOpen access · bronzeAbstract readConsensus StatementPractice Guideline
In one paragraph

Guideline in The Canadian journal of cardiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It reports registered trial NCT00458055. Cited by 104 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 4 pooled it
31.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00458055 nacompleted

Treatment Study for Severe High-Density Lipoprotein Deficiency

Ran2006Enrolled19Registered outcomes2Posted comparisons0ConditionsCoronary Arteriosclerosis, Genetic Diseases, Inborn, HypoalphalipoproteinemiasArmsAtorvastatin; Fenofibrate; Niacin
Open the trial in the graph
3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 4 syntheses or guidelines pooled it, 309 citations in OpenAlex.

  1. Effect of sleep surgery on lipid profiles in adults with obstructive sleep apnea: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Pooled it
  2. Associations of job strain and lifestyle risk factors with risk of coronary artery disease: a meta-analysis of individual participant data.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2013
    Pooled it
  3. Osteoporosis Canada 2010 guidelines for the assessment of fracture risk.Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes · 2011
    Guideline
  4. The efficacy and safety of intensive statin therapy: a meta-analysis of randomized trials.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2008
    Pooled it
  5. Communication and patient participation influencing patient recall of treatment discussions.Health expectations : an international journal of public participation in health care and health policy · 2017
    Trial
  6. Trial
  7. Trial
  8. Trial
  9. Assessment of the Siksika chronic disease nephropathy-prevention clinic.Canadian family physician Medecin de famille canadien · 2013
    Trial
  10. Trial
  11. A cluster randomized controlled Trial to Evaluate an Ambulatory primary care Management program for patients with dyslipidemia: the TEAM study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2010 · on this map
    Trial
  12. Trial
  13. The Enhancing Secondary Prevention in Coronary Artery Disease trial.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2009
    Trial
  14. Trial
  15. Efficacy of alternate day versus daily dosing of rosuvastatin.The Canadian journal of cardiology · 2009
    Trial
  16. Trial
  17. Article
  18. IL-6 and Cardiovascular Risk: A Narrative Review.Current atherosclerosis reports · 2024
    Review
  19. Article
  20. Article

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ruth McPhersonUniversity of Ottawa Heart Institute, Ottawa, Canada. rmcpherson@ottawaheart.ca
Jiri Frohlich
George Fodor
Jacques Genest
Canadian Cardiovascular Society
University of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the last publication of the recommendations for the management and treatment of dyslipidemia, new clinical trial data have emerged that support a more vigorous approach to lipid lowering in specific patient groups. The decision was made to update the lipid guidelines in collaboration with the Canadian Cardiovascular Society. A systematic electronic search of medical literature for original research consisting of blinded, randomized controlled trials was performed. Meta-analyses of studies of the efficacy and safety of lipid-lowering therapies, and of the predictive value of established and emerging risk factors were also reviewed. All recommendations are evidence-based, and have been reviewed in detail by primary and secondary review panels. Major changes include a lower low-density lipoprotein cholesterol (LDL-C) treatment target (lower than 2.0 mmol/L) for high-risk patients, a slightly higher intervention point for the initiation of drug therapy in most low-risk individuals (LDL-C of 5.0 mmol/L or a total cholesterol to high-density lipoprotein cholesterol ratio of 6.0) and recommendations regarding additional investigations of potential use in the further evaluation of coronary artery disease risk in subjects in the moderate-risk category.

Indexed as

CanadaCardiologyCardiovascular DiseasesHumansHyperlipidemiasSocieties, Medical

Identifiers

PMID16971976
PMCPMC2570238
OpenAlexW2028219942

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.