ArticleDevelopment (Cambridge, England)2006
Mosaic Eyes is a novel component of the Crumbs complex and negatively regulates photoreceptor apical size.
Article in Development (Cambridge, England), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 76 citations in OpenAlex.
- Article
- Human CRB1 and CRB2 form homo- and heteromeric protein complexes in the retina.Life science alliance · 2024Article
- Diverse functions and pathogenetic role of Crumbs in retinopathy.Cell communication and signaling : CCS · 2024Review
- Clinical and Therapeutic Evaluation of the Ten Most PrevalentBiomedicines · 2023Article
- Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model.PLoS genetics · 2022Article
- Coordinated assembly and release of adhesions builds apical junctional belts duringDevelopment (Cambridge, England) · 2020Article
- Epb41l5 interacts with Iqcb1 and regulates ciliary function in zebrafish embryos.Journal of cell science · 2020Article
- Abnormal Cone and Rod Photoreceptor Morphogenesis in gdf6a Mutant Zebrafish.Investigative ophthalmology & visual science · 2020Article
- Loss of Crb2b-lf leads to anterior segment defects in old zebrafish.Biology open · 2020Article
- Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.Scientific reports · 2019Article
- Article
- Morphogenesis of neurons and glia within an epithelium.Development (Cambridge, England) · 2019Article
- Oligomerization of the FERM-FA protein Yurt controls epithelial cell polarity.The Journal of cell biology · 2018Article
- Modulating apical-basal polarity by building and deconstructing a Yurt.The Journal of cell biology · 2018Article
- Molecular components and polarity of radial glial cells during cerebral cortex development.Cellular and molecular life sciences : CMLS · 2018Review
- CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin.PloS one · 2018Article
- Apico-basal Polarity Determinants Encoded byGenetics · 2017Article
- Biallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration.American journal of human genetics · 2017Article
- The CRB1 Complex: Following the Trail of Crumbs to a Feasible Gene Therapy Strategy.Frontiers in neuroscience · 2017Review
- Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons.Development (Cambridge, England) · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Establishment of apical-basal cell polarity has emerged as an important process during development, and the Crumbs complex is a major component of this process in Drosophila. By comparison, little is known about the role of Crumbs (Crb) proteins in vertebrate development. We show that the FERM protein Mosaic Eyes (Moe) is a novel regulatory component of the Crumbs complex. Moe coimmunoprecipitates with Ome/Crb2a and Nok (Pals1) from adult eye and in vitro interaction experiments suggest these interactions are direct. Morpholino knockdown of ome/crb2a phenocopies the moe mutations. Moe and Crumbs proteins colocalize apically and this apical localization requires reciprocal protein function. By performing genetic mosaic analyses, we show that moe- rod photoreceptors have greatly expanded apical structures, suggesting that Moe is a negative regulator of Crumbs protein function in photoreceptors. We propose that Moe is a crucial regulator of Crumbs protein cell-surface abundance and localization in embryos.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.