Trial reportObesity (Silver Spring, Md.)2006
Acute modulation of adipose tissue lipolysis by intravenous estrogens.
Trial report in Obesity (Silver Spring, Md.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02045290 (Metformin Therapy for Overweight Adolescents With Type 1 Diabetes), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metformin Therapy for Overweight Adolescents With Type 1 Diabetes (T1D)--Insulin Clamp Ancillary Study for Assessment of Insulin Resistance
Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Trial
- Timing of Estradiol Treatment After Menopause May Determine Benefit or Harm to Insulin Action.The Journal of clinical endocrinology and metabolism · 2015Trial
- Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain.Plastic and reconstructive surgery. Global open · 2024Article
- Sexual Dimorphism's impact on adipogenesis: A three-dimensional in vitro model treated with 17β-estradiol and testosterone.Molecular and cellular endocrinology · 2024Article
- A Multi-Gene Panel to Identify Lipedema-Predisposing Genetic Variants by a Next-Generation Sequencing Strategy.Journal of personalized medicine · 2022Article
- Good agreement between hyperinsulinemic-euglycemic clamp and 2 hours oral minimal model assessed insulin sensitivity in adolescents.Pediatric diabetes · 2020Article
- Aldo-Keto Reductase 1C1 (International journal of molecular sciences · 2020Article
- Sex Differences in Adipose Tissue Function.Endocrinology and metabolism clinics of North America · 2020Review
- Lipedema: A Call to Action!Obesity (Silver Spring, Md.) · 2019Review
- Oral Glucose Tolerance Test Glucose Peak Time Is Most Predictive of Prediabetes and Hepatic Steatosis in Obese Girls.Journal of the Endocrine Society · 2018Article
- Estradiol does not directly regulate adipose lipolysis.Adipocyte · 2017Article
- Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance.Obesity (Silver Spring, Md.) · 2016Article
- Serum retinol binding protein 4 is negatively related to estrogen in Chinese women with obesity: a cross-sectional study.Lipids in health and disease · 2016Article
- Modeling changes in glucose and glycerol rates of appearance when true basal rates of appearance cannot be readily determined.American journal of physiology. Endocrinology and metabolism · 2016Article
- Adrenergic control of lipolysis in women compared with men.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Subcutaneous adipose tissue insulin resistance is associated with visceral adiposity in postmenopausal women.Obesity (Silver Spring, Md.) · 2014Article
- Cause of androgenic alopecia: crux of the matter.Plastic and reconstructive surgery. Global open · 2013Article
- Lipolytic signaling in response to acute exercise is altered in female mice following ovariectomy.Journal of cellular biochemistry · 2011Article
- Age-related anabolic resistance after endurance-type exercise in healthy humans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Relationship between body fat mass and free fatty acid kinetics in men and women.Obesity (Silver Spring, Md.) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe aim of this study was to determine whether intravenous (IV) conjugated estrogens (EST) acutely enhance the suppression of whole-body or regional subcutaneous adipose tissue (SAT) lipolysis by insulin in postmenopausal women. RESEARCH METHODS AND PROCEDURES: We assessed whole-body lipolysis by [(2)H(5)]glycerol rate of appearance (Glyc(RA)) and abdominal and femoral SAT lipolysis (interstitial glycerol; Glyc(IS)) by subcutaneous microdialysis. Postmenopausal women (n = 12) were studied on two occasions, with IV EST or saline control (CON), under basal conditions and during a 3-stage (4, 8, and 40 mU/m(2)/min) hyperinsulinemic, euglycemic clamp. Ethanol outflow/inflow ratio and recovery of [(13)C]glycerol during microdialysis were used to assess blood flow changes and interstitial glycerol concentrations, respectively.
resultsCompared with CON, EST did not affect systemic basal or insulin-mediated suppression of lipolysis (Glyc(RA)) or SAT nutritive blood flow. Basal Glyc(IS) in SAT was reduced on the EST day. However, insulin-mediated suppression of lipolysis in SAT was not significantly influenced by EST. DISCUSSION: These findings suggest that estrogens acutely reduce basal lipolysis in SAT through an unknown mechanism but do not alter whole-body or SAT suppression of lipolysis by insulin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.