Evidence map›Paper›PMID 17222867›Full record

ArticleJournal of molecular biology2007

The coiled-coil domain structure of the Sin Nombre virus nucleocapsid protein.

Sergei P Boudko, Richard J Kuhn, Michael G Rossmann

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 44 citations in OpenAlex.

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  10. Structural characterization of a beta-turn mimic within a protein-protein interface.Proceedings of the National Academy of Sciences of the United States of America · 2010
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sergei P BoudkoDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907-2054, USA.
Richard J Kuhn
Michael G Rossmann
Purdue University West Lafayette · US

Funding

Structure-function studies of alpha-and flavivirusesP01AI055672 · NIAID · PURDUE UNIVERSITY WEST LAFAYETTE · PI KUHN, RICHARD J. · 2003 to 2010
$18.4M
NIAID NIH HHS AI55672NIAID NIH HHS P01 AI055672
6 · The paper itself

Abstract

Hantaviruses can cause hemorrhagic fever with a renal syndrome and hantavirus pulmonary syndrome when transmitted to humans. The nucleocapsid protein of hantaviruses encapsidates viral genomic RNA and associates with transcription and replication complexes. Both the amino and carboxy termini of the nucleocapsid protein had been predicted to form trimers prior to the formation of the ribonucleoprotein. Crystal structures of amino-terminal fragments of the nucleocapsid protein showed the formation of intramolecular antiparallel coiled coils, but not intermolecular trimers. Thus, the amino-terminal part of the nucleocapsid protein is probably insufficient to initiate the trimerization of the full-length molecule.

Indexed as

Amino Acid SequenceCrystallography, X-RayEscherichia coliHumansLightModels, BiologicalModels, MolecularMolecular Sequence DataNucleocapsid ProteinsProtein ConformationProtein Structure, SecondaryProtein Structure, TertiaryRecombinant Fusion ProteinsScattering, RadiationSequence Homology, Amino AcidSin Nombre virusNucleocapsid ProteinsRecombinant Fusion Proteins

Identifiers

PMID17222867
PMCPMC1820746
OpenAlexW2150808506

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.