ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2007
Sex differences in the effectiveness of statins after myocardial infarction.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Sex differences in long-term mortality after myocardial infarction: a systematic review.Circulation · 2014Pooled it
- Bias in observational studies of prevalent users: lessons for comparative effectiveness research from a meta-analysis of statins.American journal of epidemiology · 2012Pooled it
- Simvastatin and dehydroepiandrosterone sulfate effects against hypoxic pulmonary hypertension are not additive.Physiological research · 2022Article
- Sex Difference in Control of Low-Density Lipoprotein Cholesterol in Older Patients after Acute Coronary Syndrome.Geriatrics (Basel, Switzerland) · 2022Article
- Increasing likelihood of prescribing recommended lipid management: Primary care providers' participation in cardiology continuing medical education.Canadian family physician Medecin de famille canadien · 2022Article
- Sex-Specific Associations Between Serum Lipids, Antinuclear Antibodies, and Statin Use in National Health and Nutrition Examination Surveys 1999-2004.Frontiers in medicine · 2022Article
- Sex disparities and adverse cardiovascular and kidney outcomes in patients with chronic kidney disease: results from the KNOW-CKD.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Observational
- Impact of Statin Use on Dementia Incidence in Elderly Men and Women with Ischemic Heart Disease.Biomedicines · 2020Article
- Are There Sex-Specific Differences in Response to Adjunctive Host-Directed Therapies for Tuberculosis?Frontiers in immunology · 2020Article
- Cardiovascular Risks Associated with Gender and Aging.Journal of cardiovascular development and disease · 2019Review
- Gender Dictates the Relationship between Serum Lipids and Leukocyte Counts in the National Health and Nutrition Examination Survey 1999⁻2004.Journal of clinical medicine · 2019Article
- Sex-Interacting mRNA- and miRNA-eQTLs and Their Implications in Gene Expression Regulation and Disease.Frontiers in genetics · 2019Article
- Gender in Endocrine Diseases: Role of Sex Gonadal Hormones.International journal of endocrinology · 2018Review
- Article
- Quality of cardiovascular disease care in Ontario's primary care practices: a cross sectional study examining differences in guideline adherence by patient sex.BMC family practice · 2014Article
- Observational
- Presentation, management, and outcomes of ischaemic heart disease in women.Nature reviews. Cardiology · 2013Review
- Breakout session: Gender and ethnic disparities in pain management.Clinical orthopaedics and related research · 2011Article
- Sex/gender medicine. The biological basis for personalized care in cardiovascular medicine.Circulation journal : official journal of the Japanese Circulation Society · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe sought to investigate the sex differences in the effectiveness of statins in patients with acute myocardial infarction (AMI).
methodsLinking hospital discharge and drug claims databases from Quebec, Canada (1998-2004), we identified statin users (n = 14 710) and non-users (n = 23 833) discharged from hospital after an AMI-related hospital stay and followed up for as long as 7 years.
resultsAll-cause death rates were 4.1 and 14.6 per 100 person-years among users and non-users, respectively, whereas cardiac death rates were 2.2 and 7.4 per 100 person-years. For death from any cause, the adjusted hazard ratios associated with statin use in women were 0.61 (95% confidence interval [CI], 0.54-0.69) within 1 year of follow-up, 0.55 (0.48-0.63) at 1-3 years and 0.38 (0.31-0.49) at > 3 years; in men, the corresponding estimates were 0.54 (0.48-0.60), 0.48 (0.42-0.55) and 0.34 (0.30-0.39). For cardiac-related death, the adjusted hazard ratios associated with statin use in women were 0.70 (0.60-0.81) within 1 year, 0.56 (0.46-0.68) at 1-3 years and 0.44 (0.31-0.62) at > 3 years of follow-up, whereas in men, the estimates were 0.59 (0.51-0.69), 0.47 (0.39-0.58) and 0.37 (0.30-0.45), respectively.
interpretationStatin therapy after an AMI was associated with reduced rates of all-cause and cardiac mortality. The effect increased with time in both sexes, but the degree of risk reduction was less for women than for men.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.