ArticleJournal of cellular physiology2007
Agonist-induced calcium entry correlates with STIM1 translocation.
Article in Journal of cellular physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- iPLACells · 2021Article
- Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease.Nature communications · 2016Article
- ORAI1 calcium channel orchestrates skin homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Lysophosphatidic acid promotes cell migration through STIM1- and Orai1-mediated Ca2+(i) mobilization and NFAT2 activation.The Journal of investigative dermatology · 2013Article
- Role of STIM1- and Orai1-mediated Ca2+ entry in Ca2+-induced epidermal keratinocyte differentiation.Journal of cell science · 2013Article
- Overexpression of Orai1 and STIM1 proteins alters regulation of store-operated Ca2+ entry by endogenous mediators.The Journal of biological chemistry · 2012Article
- Orai1 and Ca2+-independent phospholipase A2 are required for store-operated Icat-SOC current, Ca2+ entry, and proliferation of primary vascular smooth muscle cells.American journal of physiology. Cell physiology · 2012Article
- Cyclic nucleotide-dependent relaxation pathways in vascular smooth muscle.Cellular and molecular life sciences : CMLS · 2012Review
- Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention.Chemical reviews · 2011Review
- S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells.American journal of physiology. Cell physiology · 2011Article
- Chemico-genetic identification of drebrin as a regulator of calcium responses.The international journal of biochemistry & cell biology · 2010Article
- How strict is the correlation between STIM1 and Orai1 expression, puncta formation, and ICRAC activation?American journal of physiology. Cell physiology · 2008Article
- New insights into the activation mechanism of store-operated calcium channels: roles of STIM and Orai.Journal of Zhejiang University. Science. B · 2008Review
- Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps.Molecular biology of the cell · 2008Article
- Orai, STIM1 and iPLA2beta: a view from a different perspective.The Journal of physiology · 2008Article
- Novel role for STIM1 as a trigger for calcium influx factor production.The Journal of biological chemistry · 2008Article
- Inhibition of calcium-independent phospholipase A impairs agonist-induced calcium entry in keratinocytes.The British journal of dermatology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The mechanisms of agonist-induced calcium entry (ACE) following depletion of intracellular calcium stores have not been fully established. We report here that calcium-independent phospholipase A (iPLA(2)) is required for robust Ca(2+) entry in HaCaT keratinocytes following ATP or UTP stimulation. Lysophosphatidic acid (LPA), an unrelated agonist, evoked Ca(2+) release without inducing robust Ca(2+) entry. Both LPA and UTP induced the redistribution of STIM1 into puncta which localized to regions near or at the plasma membrane, as well as within the cytoplasm. Plasma membrane-associated STIM1 remained high for up to 10 min after UTP stimulation, whereas it had returned almost to baseline by that time point in LPA-stimulated cells. This correlated with faster reloading of the endoplasmic reticulum Ca(2+) stores in LPA treated cells. Thus by differentially regulating store-refilling after agonist-mediated depletion, LPA and UTP may exert distinct effects on the duration of STIM1 localization at the plasma membrane, and thus, on the magnitude and duration of ACE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.