Trial reportClinical pharmacology and therapeutics2007
Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin.
Trial report in Clinical pharmacology and therapeutics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06841536 (Combined Effects of Statins and Exercise on Physiological Health Markers and Quality of Life in Patients With Dyslipidaemia), which is not on this map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combined Effects of Statins and Exercise on Physiological Health Markers and Quality of Life in Patients With Dyslipidaemia
Who cites it
35 citing papers in PubMed, 102 citations in OpenAlex.
- Simvastatin impairs exercise training adaptations.Journal of the American College of Cardiology · 2013 · on this mapTrial
- Beyond Cholesterol Lowering: Clinical Caution, Personalization, and Nutritional Integration in Statin Therapy.Nutrients · 2026Review
- Article
- High-dose atorvastatin therapy progressively decreases skeletal muscle mitochondrial respiratory capacity in humans.JCI insight · 2024 · on this mapArticle
- Effects of statins on mitochondrial pathways.Journal of cachexia, sarcopenia and muscle · 2021Review
- Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected.Scientific reports · 2021Article
- Statins interfere with the attachment ofJournal of enzyme inhibition and medicinal chemistry · 2020Article
- Exercise-Pharmacology Interactions: Metformin, Statins, and Healthspan.Physiology (Bethesda, Md.) · 2020Review
- Lipid-lowering Therapies in Myositis.Current rheumatology reports · 2020Review
- Endurance exercise increases the protein levels of PGC-1α and respiratory chain complexes in mouse skeletal muscle during atorvastatin administration.The journal of physiological sciences : JPS · 2019Article
- Mitochondrial disorders and drugs: what every physician should know.Drugs in context · 2019Review
- Statin-Associated Cardiomyopathy Responds to Statin Withdrawal and Administration of Coenzyme QThe Permanente journal · 2019Article
- An image-based small-molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Sources of Inter-individual Variability in the Therapeutic Response of Blood Glucose Control to Exercise in Type 2 Diabetes: Going Beyond Exercise Dose.Frontiers in physiology · 2018Review
- Statins, Muscle Disease and Mitochondria.Journal of clinical medicine · 2017Review
- Curcumin: An effective adjunct in patients with statin-associated muscle symptoms?Journal of cachexia, sarcopenia and muscle · 2017Review
- Skeletal muscle metabolic adaptations to endurance exercise training are attainable in mice with simvastatin treatment.PloS one · 2017Article
- Molecular mechanisms of statin intolerance.Archives of medical science : AMS · 2016Article
- Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management.European heart journal · 2015Review
- Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Statins are generally well tolerated, but can cause myopathy and have been associated with mitochondrial abnormalities. The aim of this study was to determine whether muscle mitochondrial DNA (mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published clinical trial of high-dose simvastatin or atorvastatin versus placebo.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.