Evidence map›Paper›PMID 17335677›Full record

ReviewCurrent gastroenterology reports2007

Treatment of fibrosis in nonalcoholic fatty liver disease.

Maarouf A Hoteit, Frank A Anania

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current gastroenterology reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Mechanisms of hepatic fibrogenesis.Best practice & research. Clinical gastroenterology · 2011
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maarouf A HoteitDivision of Digestive Diseases, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael Street, Room 248, Atlanta, GA 30322, USA.
Frank A Anania
Emory University · US

Funding

Emory Epithelial Pathobiology Research Development CenterR24DK064399 · NIDDK · EMORY UNIVERSITY · PI PARKOS, CHARLES A · 2003 to 2012
$5.3M
The Role of Leptin in Liver FibrogenesisR01DK062092 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI ANANIA, FRANK A · 2003 to 2016
$3.9M
The Role of Leptin in Liver FibrogenesisR56DK062092 · NIDDK · EMORY UNIVERSITY · PI ANANIA, FRANK A · 2012 to 2012
$207k
NIDDK NIH HHS DK062092NIDDK NIH HHS DK064399
6 · The paper itself

Abstract

Nonalcoholic steatohepatitis (NASH) is one of the most common liver disorders in North America. The mechanism of liver injury in NASH involves insulin resistance and oxidative stress as well as cytokine release. Therapeutic interventions aimed at enhancing insulin sensitivity or reducing oxidative stress have been studied. The role of peptide hormones secreted by adipose tissue--adipocytokines--in the potential pathogenesis of NASH is an area of intense research. As the function of adipokines in modulating hepatic inflammation and fibrosis is elucidated, the potential for novel treatment strategies in patients with NASH is likely to be realized.

Indexed as

AdiponectinAdipose TissueAnimalsAntioxidantsCytokinesFatty LiverHumansHypoglycemic AgentsInsulin ResistanceLiver CirrhosisMetabolic SyndromeMetforminOxidative StressRisk FactorsThiazolidinedionesTransaminasesAdiponectinADIPOQ protein, humanAntioxidantsCytokinesHypoglycemic AgentsMetforminThiazolidinedionesTransaminases

Identifiers

PMID17335677
OpenAlexW2022295585

What Socratic holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.