ReviewCurrent cardiology reports2007
Myocardial metabolism and cardiac performance in obesity and insulin resistance.
Review in Current cardiology reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02910154 (Comprehensive Treatment of Angina in Women With Microvascular Dysfunction - a Proof of Concept Study of the iPower Cohort), which is not on this map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comprehensive Treatment of Angina in Women With Microvascular Dysfunction - a Proof of Concept Study of the iPower Cohort
Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- Cardiometabolic disease risk in gorillas is associated with altered gut microbial metabolism.NPJ biofilms and microbiomes · 2025Article
- Adiponectin receptor agonist ameliorates cardiac lipotoxicity via enhancing ceramide metabolism in type 2 diabetic mice.Cell death & disease · 2022Article
- Obesity cardiomyopathy: the role of obstructive sleep apnea and obesity hypoventilation syndrome.Irish journal of medical science · 2019Review
- Article
- Lifestyle modification interventions differing in intensity and dietary stringency improve insulin resistance through changes in lipoprotein profiles.Obesity science & practice · 2016Article
- Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation.American journal of physiology. Endocrinology and metabolism · 2014Article
- Obesity Disease and Surgery.International journal of chronic diseases · 2014Review
- Adrenergic receptors and metabolism: role in development of cardiovascular disease.Frontiers in physiology · 2013Review
- Diacylglycerol acyl transferase 1 overexpression detoxifies cardiac lipids in PPARγ transgenic mice.Journal of lipid research · 2012Article
- Myocardial oxygen consumption change predicts left ventricular relaxation improvement in obese humans after weight loss.Obesity (Silver Spring, Md.) · 2011Article
- Effect of maternal nutrient restriction from early to midgestation on cardiac function and metabolism after adolescent-onset obesity.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Mechanisms of heart failure in obesity.Obesity research & clinical practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity, insulin resistance, and their frequent complication of type 2 diabetes are risk factors for left ventricular diastolic dysfunction, systolic dysfunction, and clinical heart failure. Although obesity, insulin resistance, and diabetes are risk factors for coronary artery disease, and hence ischemic cardiomyopathy-related heart failure, there is increasing evidence that these three risk factors are implicated in the development of cardiac dysfunction not related to epicardial coronary disease. There are several mechanisms by which this triad may cause cardiac dysfunction, including alterations in myocardial metabolism, which may initially be adaptations but evolve into maladaptive responses over time. Recent advances in our understanding of these mechanisms will aid in the development of novel therapies, including metabolic manipulations that could prevent and treat cardiac dysfunction in patients with obesity, insulin resistance, and diabetes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.