Evidence map›Paper›PMID 17488472›Full record

ReviewJournal of cellular and molecular medicine

The extracellular matrix and blood vessel formation: not just a scaffold.

John M Rhodes, Michael Simons

Abstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Matrix stiffness induces endothelial network senescence.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Expression of Versican in the Retina and Its Implication in Retinal Disease.Advances in experimental medicine and biology · 2025
    Review
  15. Vascular Extracellular Matrix in Atherosclerosis.International journal of molecular sciences · 2024
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John M RhodesAngiogenesis Research Center, Section of Cardiology, Departments of Medicine and Pharmacology & Toxicology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA.
Michael Simons

Funding

SYNDECAN FUNCTION IN ENDOTHELIAL CELLSR01HL062289 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL · 1999 to 2021
$9.6M
NHLBI NIH HHS HL 62289NHLBI NIH HHS R01 HL062289
6 · The paper itself

Abstract

The extracellular matrix plays a number of important roles, among them providing structural support and information to cellular structures such as blood vessels imbedded within it. As more complex organisms have evolved, the matrix ability to direct signalling towards the vasculature and remodel in response to signalling from the vasculature has assumed progressively greater importance. This review will focus on the molecules of the extracellular matrix, specifically relating to vessel formation and their ability to signal to the surrounding cells to initiate or terminate processes involved in blood vessel formation.

Indexed as

Neovascularization, PhysiologicAnimalsExtracellular MatrixExtracellular Matrix ProteinsHumansExtracellular Matrix Proteins

Identifiers

PMID17488472
PMCPMC3822822

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.