ArticleThe Journal of physiology2007
Prenatal stress in the rat results in increased blood pressure responsiveness to stress and enhanced arterial reactivity to neuropeptide Y in adulthood.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood.Development and psychopathology · 2021Article
- Sex Differences in the Neuropeptide Y System and Implications for Stress Related Disorders.Biomolecules · 2020Review
- The Hypothalamic-Pituitary-Adrenal Axis: Development, Programming Actions of Hormones, and Maternal-Fetal Interactions.Frontiers in behavioral neuroscience · 2020Review
- Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Evidence for Ancestral Programming of Resilience in a Two-Hit Stress Model.Frontiers in behavioral neuroscience · 2017Article
- Prenatal stress-immune programming of sex differences in comorbidity of depression and obesity/metabolic syndrome.Dialogues in clinical neuroscience · 2016Review
- Emotional Stress and Cardiovascular Complications in Animal Models: A Review of the Influence of Stress Type.Frontiers in physiology · 2016Review
- Chronic prenatal stress epigenetically modifies spinal cord BDNF expression to induce sex-specific visceral hypersensitivity in offspring.Neurogastroenterology and motility · 2014Article
- Gender-dependent resiliency to stressful and metabolic challenges following prenatal exposure to high-fat diet in the p66(Shc-/-) mouse.Frontiers in behavioral neuroscience · 2014Article
- Prenatal exposure to dexamethasone in the mouse alters cardiac growth patterns and increases pulse pressure in aged male offspring.PloS one · 2013Article
- Experimental manipulations blunt time-induced changes in brain monoamine levels and completely reverse stress, but not Pb+/-stress-related modifications to these trajectories.Behavioural brain research · 2009Article
- Alterations in glucocorticoid negative feedback following maternal Pb, prenatal stress and the combination: a potential biological unifying mechanism for their corresponding disease profiles.Toxicology and applied pharmacology · 2009Article
- Influence of low level maternal Pb exposure and prenatal stress on offspring stress challenge responsivity.Neurotoxicology · 2008Article
- Genetic predisposition to hypertension sensitizes borderline hypertensive rats to the hypertensive effects of prenatal glucocorticoid exposure.The Journal of physiology · 2008Article
- Ingenuity pathway analysis of clozapine-induced obesity.Obesity facts · 2008Article
- The effects of progressive muscular relaxation and breathing control technique on blood pressure during pregnancy.Iranian journal of nursing and midwifery researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have shown previously that stress in the pregnant rat leads to a heightened cardiovascular response to restraint in adult offspring. The present study was undertaken to explore further the persistent cardiovascular effects of prenatal stress, with a focus on peripheral vascular function. Sprague-Dawley female rats were exposed to restraint/bright light three times daily in the last week of pregnancy. Litters from stressed and control females were cross-fostered to control dams to eliminate possible effects of maternal stress on nursing behaviour. At 120 days, offspring cardiovascular variables were measured by radiotelemetry. Reactivity of mesenteric small arteries was assessed by myography, and responses to electrical field stimulation determined. Resting cardiovascular parameters in prenatally stressed (PS) offspring were similar to controls but PS rats showed a greater increase in systolic blood pressure following restraint stress (P<0.05). Recovery was also prolonged in PS animals compared with controls and was of longer duration in PS females than in PS males (P<0.05). Adult PS females, but not males, also had elevated basal plasma corticosterone levels in comparison with controls (P<0.05). Vascular reactivity to neuropeptide Y (P<0.05) and electrical field stimulation (P<0.05) in mesenteric arteries was also significantly increased in PS animals. Vascular responses to adrenergic agonists as well as endothelial dilator function did not differ between PS and controls. We conclude that prenatal stress during late gestation has long-lasting effects on cardiovascular responsiveness and vascular reactivity to neuropeptide Y in the offspring.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.