ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2007
The systolic to diastolic duration ratio in children with hypoplastic left heart syndrome: a novel Doppler index of right ventricular function.
Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07482943 (The Effect of Dapagliflozin on Exercise and Cardiac Functional Status of Patients After Fontan Procedure), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Dapagliflozin on Exercise and Cardiac Functional Status of Patients After Fontan Procedure
Who cites it
18 citing papers in PubMed.
- Comparison of echocardiographic measurements to invasive measurements of diastolic function in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial.Cardiology in the young · 2019Trial
- Tricuspid annular plane systolic excursion correlates with exercise capacity in a cohort of patients with hypoplastic left heart syndrome after Fontan operation.Echocardiography (Mount Kisco, N.Y.) · 2016Trial
- Noninvasive Evaluation of Ventricular Filling Pressure and Pulmonary Vascular Reserve in Adults With Fontan Circulation.Journal of the American Heart Association · 2025Article
- Multimodal Imaging from Fetal to Adult Life: A Comprehensive Approach to Hypoplastic Left Heart Syndrome (HLHS).Journal of cardiovascular development and disease · 2025Review
- Echocardiographic Strain to Predict Need for Transplant or Mortality in Fontan Patients with Hypoplastic Left Heart Syndrome.Pediatric cardiology · 2024Article
- Hybrid Palliation for Hypoplastic Left Heart Syndrome: Role of Echocardiography.Children (Basel, Switzerland) · 2023Review
- A guide to echocardiographic assessment in children and adolescents with pulmonary hypertension.Cardiovascular diagnosis and therapy · 2021Review
- Study of the Correlation Between the Ratio of Diastolic to Systolic Durations and Echocardiography Measurements and Its Application to the Classification of Heart Failure Phenotypes.International journal of general medicine · 2021Article
- Longitudinal changes in echocardiographic measures of ventricular function after Fontan operation.Echocardiography (Mount Kisco, N.Y.) · 2020Observational
- Deformation pattern and predictive value of right ventricular longitudinal strain in children with pulmonary arterial hypertension.Cardiovascular ultrasound · 2016Article
- Transthoracic echocardiography in the evaluation of pediatric pulmonary hypertension and ventricular dysfunction.Pulmonary circulation · 2016Review
- Differences in Eccentricity Index and Systolic-Diastolic Ratio in Extremely Low-Birth-Weight Infants with Bronchopulmonary Dysplasia at Risk of Pulmonary Hypertension.American journal of perinatology · 2016Article
- Left ventricle after palliation of hypoplastic left heart syndrome: friend, fiend, or innocent bystander?Pediatric cardiology · 2013Review
- Doppler flow patterns in the right ventricle-to-pulmonary artery shunt and neo-aorta in infants with single right ventricle anomalies: impact on outcome after initial staged palliations.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2013Article
- Subjective evaluation of right ventricular systolic function in hypoplastic left heart syndrome: how accurate is it?Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2013Article
- Non-Invasive Imaging for Congenital Heart Disease: Recent Innovations in Transthoracic Echocardiography.Journal of clinical & experimental cardiology · 2012Article
- Transthoracic echocardiography in children and young adults with congenital heart disease.ISRN pediatrics · 2012Article
- Diminished right ventricular function at diagnosis of pulmonary hypertension is associated with mortality in bronchopulmonary dysplasia.Pulmonary circulationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRight ventricular (RV) function is an important determinant of clinical status in children with hypoplastic left heart syndrome (HLHS). However, assessment of RV function remains challenging because of its complex morphology. We investigated the S/D duration ratio in children with HLHS as a novel index of global RV function.
methodsWe measured systolic (S) and diastolic (D) duration using tricuspid regurgitation duration from Doppler flow, to calculate the S/D ratio in 33 children with HLHS and 33 control subjects matched for age and sex. We compared the S/D ratio between patients with HLHS and control subjects, between patients with HLHS and normal and abnormal RV function, and between patients with HLHS at different stages of palliation. We further correlated the S/D ratio with catheterization data.
resultsPatients and control subjects were well matched for age (3.12 +/- 4.5 vs 3 +/- 4.5 years, not significant) sex, and heart rate (cycle length 524 +/- 179 vs 575 +/- 162 milliseconds, not significant). Patients with HLHS had a significantly higher S/D ratio than control subjects (1.65 +/- 0.85 vs 0.85 +/- 0.2, P < .0001). The S/D ratio became increasingly elevated in HLHS at higher heart rates, but not in control subjects. The S/D ratio was significantly higher in patients with HLHS and decreased RV function as compared with patients with HLHS and normal RV function (2.2 +/- 0.7 vs 1.5 +/- 0.47, P = .006), and significantly increased in patients with Norwood stage 1 versus patients with Norwood stages 2 and 3 HLHS (2.16 vs 1.4 and 1.32, respectively, P < .01 and P < .001, respectively). The S/D ratio did not correlate with catheterization-derived RV end-D pressure or cardiac index.
conclusionsPatients with HLHS have an increased S/D ratio as a result of a shortened D and prolonged S. Measurement of the S/D duration ratio using Doppler flow is a novel method to augment assessment of global RV function in HLHS.
Indexed as
Identifiers
17543747What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.