Trial reportThe American journal of cardiology2007
Rationale and design for the blood pressure intervention of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.
Trial report in The American journal of cardiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00000620. Cited by 57 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Action to Control Cardiovascular Risk in Diabetes (ACCORD)
Who cites it
57 citing papers in PubMed, 13 syntheses or guidelines pooled it.
- [Cardiovascular preventive recommendations. PAPPS 2024 thematic updates].Atencion primaria · 2024Guideline
- Blood pressure control for diabetic retinopathy.The Cochrane database of systematic reviews · 2023Pooled it
- Blood pressure targets for the treatment of people with hypertension and cardiovascular disease.The Cochrane database of systematic reviews · 2022Pooled it
- Pharmacological treatment of hypertension in people without prior cerebrovascular disease for the prevention of cognitive impairment and dementia.The Cochrane database of systematic reviews · 2021Pooled it
- Blood pressure targets for the treatment of people with hypertension and cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- 2019 AHA/ACC Clinical Performance and Quality Measures for Adults With High Blood Pressure: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures.Journal of the American College of Cardiology · 2019Guideline
- 2019 AHA/ACC Clinical Performance and Quality Measures for Adults With High Blood Pressure: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures.Circulation. Cardiovascular quality and outcomes · 2019Guideline
- Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease.The Cochrane database of systematic reviews · 2018Pooled it
- Blood pressure targets for the treatment of people with hypertension and cardiovascular disease.The Cochrane database of systematic reviews · 2018Pooled it
- Blood pressure targets for the treatment of people with hypertension and cardiovascular disease.The Cochrane database of systematic reviews · 2017Pooled it
- Glucose targets for preventing diabetic kidney disease and its progression.The Cochrane database of systematic reviews · 2017Pooled it
- Blood pressure control for diabetic retinopathy.The Cochrane database of systematic reviews · 2015Pooled it
- Standards of medical care in diabetes--2010.Diabetes care · 2010 · on this mapGuideline
- Time in target range of systolic blood pressure and eGFR slope in patients with type 2 diabetes.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Trial
- Refining determinants of associations of visit-to-visit blood pressure variability with cardiovascular risk: results from the Action to Control Cardiovascular Risk in Diabetes Trial.Journal of hypertension · 2021Trial
- Trial
- Blood Pressure Measurement in SPRINT (Systolic Blood Pressure Intervention Trial).Hypertension (Dallas, Tex. : 1979) · 2018Trial
- BP in Dialysis: Results of a Pilot Study.Journal of the American Society of Nephrology : JASN · 2018Trial
- Systolic Blood Pressure Control Among Individuals With Type 2 Diabetes: A Comparative Effectiveness Analysis of Three Interventions.American journal of hypertension · 2015Trial
- Intensive blood pressure control, falls, and fractures in patients with type 2 diabetes: the ACCORD trial.Journal of general internal medicine · 2014Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
The Action to Control Cardiovascular Disease in Diabetes (ACCORD) blood pressure trial is an unmasked, open-label, randomized trial with a sample size of 4,733 participants. This report describes the rationale, design, and methods of the blood pressure interventions in ACCORD. Participants eligible for the blood pressure trial are randomized to 1 of 2 groups with different treatment goals: systolic blood pressure <120 mm Hg for the more intensive goal and systolic blood pressure <140 mm Hg for the less intensive goal. The primary outcome measure for the trial is the first occurrence of a major cardiovascular disease (CVD) event, specifically nonfatal myocardial infarction or stroke, or cardiovascular death during a follow-up period ranging from 4-8 years. The ACCORD blood pressure trial should provide the first definitive clinical trial data on the possible benefit of treating to a more aggressive systolic blood pressure goal in reducing CVD events in patients with diabetes mellitus.
Indexed as
Identifiers
17599425What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.