ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2007
Effectiveness of antiresorptive agents in the prevention of recurrent hip fractures.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Fractures reduction with osteoporotic treatments in patients over 75-year-old: A systematic review and meta-analysis.Frontiers in aging · 2022Pooled it
- Bisphosphonates and osteoporotic fractures: a cross-design synthesis of results among compliant/persistent postmenopausal women in clinical practice versus randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010Pooled it
- Effectiveness of treatment initiation for secondary fracture prevention in the older population: Japanese Bone-fracture Osteoporosis in Late-stage population Database study (J-BOLD) - emulation of a randomized target trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Trial
- Effect of bisphosphonate initiation at week 2 versus week 12 on short-term functional recovery after femoral neck fracture: a randomized controlled trial.Archives of osteoporosis · 2017Trial
- Identification of factors predictive of contralateral secondary hip fractures in patients after initial hip fracture - A prospective observational study.Bone reports · 2026Article
- Changes in Characteristics and Outcomes of Patients Undergoing Surgery for Hip Fractures Following the Initiation of Orthogeriatric Service: Temporal Trend Analysis.Calcified tissue international · 2022Article
- Real-life short-term effectiveness of anti-osteoporotic treatments: a longitudinal cohort study.Therapeutic advances in musculoskeletal disease · 2022Article
- Real-world effectiveness of osteoporosis treatment in the oldest old.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Alendronate medication possession ratio and the risk of second hip fracture: an 11-year population-based cohort study in Taiwan.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Epidemiology and risk factors for contralateral proximal femur fracture: a single center retrospective cohort study on 1022 patients.Acta bio-medica : Atenei Parmensis · 2020Article
- Secular trends in incidence and recurrence rates of hip fracture: a nationwide population-based study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Comparison of Statistical Approaches for Dealing With Immortal Time Bias in Drug Effectiveness Studies.American journal of epidemiology · 2016Article
- Vibration Therapy to Prevent Bone Loss and Falls: Mechanisms and Efficacy.Current osteoporosis reports · 2015Review
- Established Osteoporosis and Gaps in the Management: Review from a Teaching hospital.Annals of medical and health sciences research · 2014Article
- Temporal trends in the incidence of osteoporotic fractures.Current osteoporosis reports · 2013Review
- Treatment of osteoporosis in postmenopausal hip fracture patients after geriatric rehabilitation: changes over the last decade.Zeitschrift fur Gerontologie und Geriatrie · 2011Article
- Longitudinal change in hip fracture incidence after starting risedronate or raloxifene: an observational study.Journal of bone and mineral metabolism · 2011Article
- Methods to examine the impact of compliance to osteoporosis pharmacotherapy on fracture risk: systematic review and recommendations.Therapeutic advances in chronic disease · 2010Article
- Prevention and clinical management of hip fractures in patients with dementia.Geriatric orthopaedic surgery & rehabilitation · 2010Article
- Longitudinal change in clinical fracture incidence after initiation of bisphosphonates.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledHip fracture is associated with recurrent fractures and increased mortality. The results of our retrospective cohort study support the use of antiresorptive agents to prevent recurrent hip fractures in this population.
introductionHip fracture, the most serious consequence of osteoporosis, is associated with recurrent fractures and increased mortality. Antiresorptive therapy has proven efficacy in the prevention of fractures after vertebral fractures. It is unknown if it can prevent recurrent fractures after a hip fracture.
methodsWe designed a population based, retrospective cohort study, using administrative databases and identified patients hospitalized for a hip fracture between 1996 and 2002. The exposure was defined as being dispensed a prescription for an antiresorptive agent at any time following discharge. Multivariate Cox regression models were used to estimate the hazard ratio of recurrent hip fracture. Subgroup and propensity score analyses were performed.
resultsA total of 20,644 patients were identified; 6,779 filled a prescription for antiresorptive agents. There were 992 recurrent hip fractures. Patients exposed to antiresorptives had a 26% reduction in the rate of recurrent fractures (adjusted hazard ratio 0.74; 95% CI, 0.64-0.86) compared to patients who were not. All subgroups experienced a reduction in recurrent fracture, except the very elderly. Propensity score analyses were consistent with the main analysis.
conclusionsAntiresorptive therapy reduces the risk of recurrent hip fractures in elderly patients. These results provide evidence that this therapy should be considered for secondary prevention of hip fractures.
Indexed as
Identifiers
17634854What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.