ArticleYakugaku zasshi : Journal of the Pharmaceutical Society of Japan2007
Formulation and optimization of sustained release matrix tablet of metformin HCl 500 mg using response surface methodology.
Article in Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00941161 (Effect of Oral Combination Therapy of Metformin Extended Release Over Glimepiride in a Single Dosage Form in Patients With Type 2 Diabetes Mellitus With Failure of Monotherapy), which is not on this map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Oral Combination Therapy of Metformin Extended Release Over Glimepiride in a Single Dosage Form in Patients With Type 2 Diabetes Mellitus With Failure of Monotherapy
Who cites it
10 citing papers in PubMed, 61 citations in OpenAlex.
- Rapid dissolving microneedle patch integrated with benidipine-loaded nanotransfersomes for transdermal drug delivery: optimization, characterizations, and preclinical bioavailability assessment.Drug delivery and translational research · 2026Article
- Bioequivalence and Safety Assessment of Two Formulations of Metformin Hydrochloride Sustained-Release Tablets (YuantangDrugs in R&D · 2022Article
- Single Layer Extended Release Two-in-One Guaifenesin Matrix Tablet: Formulation Method, Optimization, Release Kinetics Evaluation and Its Comparison with MucinexIranian journal of pharmaceutical research : IJPR · 2017Article
- Design and In-vitro Evaluation of Sustained Release Floating Tablets of Metformin HCl Based on Effervescence and Swelling.Iranian journal of pharmaceutical research : IJPR · 2016Article
- Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application.International journal of nanomedicine · 2014Article
- Formulation development and optimization of sustained release matrix tablet of Itopride HCl by response surface methodology and its evaluation of release kinetics.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2013Article
- Metformin loaded non-ionic surfactant vesicles: optimization of formulation, effect of process variables and characterization.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2013Article
- Use of response surface methodology in the formulation and optimization of bisoprolol fumarate matrix tablets for sustained drug release.ISRN pharmaceutics · 2012Article
- Effect of Kollidon® SR on the release of Albuterol Sulphate from matrix tablets.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2011Article
- Development and evaluation of in situ gel of pregabalin.International journal of pharmaceutical investigationArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the current study was to design an oral sustained release matrix tablet of metformin HCl and to optimize the drug release profile using response surface methodology. Tablets were prepared by non-aqueous wet granulation method using HPMC K 15M as matrix forming polymer. A central composite design for 2 factors at 3 levels each was employed to systematically optimize drug release profile. HPMC K 15M (X(1)) and PVP K 30 (X(2)) were taken as the independent variables. The dependent variables selected were % of drug released in 1 hr (rel(1 hr)), % of drug released in 8 hrs (rel(8 hrs)) and time to 50% drug release (t(50%)). Contour plots were drawn, and optimum formulations were selected by feasibility and grid searches. The formulated tablets followed Higuchi drug release kinetics and diffusion was the dominant mechanism of drug release, resulting in regulated and complete release within 8 hrs. The polymer (HPMC K 15M) and binder (PVP K 30) had significant effect on the drug release from the tablets (p<0.05). Polynomial mathematical models, generated for various response variables using multiple linear regression analysis, were found to be statistically significant (p<0.05). Validation of optimization study, performed using 8 confirmatory runs, indicated very high degree of prognostic ability of response surface methodology, with mean percentage error (+/-S.D.) 0.0437+/-0.3285. Besides unraveling the effect of the 2 factors on the in vitro drug release, the study helped in finding the optimum formulation with sustained drug release.
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