ArticleJournal of the American College of Cardiology2007
Volume-to-creatinine clearance ratio: a pharmacokinetically based risk factor for prediction of early creatinine increase after percutaneous coronary intervention.
Article in Journal of the American College of Cardiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04766008 (Metformin Continuation Safety in Diabetic Patients Undergoing Coronary Angiography), which is not on this map. Cited by 116 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metformin Continuation Safety in Diabetic Patients Undergoing Coronary Angiography
Who cites it
116 citing papers in PubMed, 6 syntheses or guidelines pooled it, 368 citations in OpenAlex.
- Guideline on the use of iodinated contrast media in patients with kidney disease 2018.Clinical and experimental nephrology · 2020Guideline
- Preventing contrast medium-induced acute kidney injury : Side-by-side comparison of Swedish-ESUR guidelines.European radiology · 2018Pooled it
- Pooled it
- Guidelines on the use of iodinated contrast media in patients with kidney disease 2012: digest version. JSN, JRS, and JCS Joint Working Group.Japanese journal of radiology · 2013Guideline
- Guidelines on the use of iodinated contrast media in patients with kidney disease 2012: digest version : JSN, JRS, and JCS Joint Working Group.Clinical and experimental nephrology · 2013Guideline
- Cardiological Society of India practice guidelines for angiography in patients with renal dysfunction.Indian heart journal · 2012Guideline
- Left ventricular end-diastolic pressure-guided hydration for the prevention of contrast-induced acute kidney injury in patients with stable ischemic heart disease: the LAKESIDE trial.International urology and nephrology · 2019Trial
- Comparison of magnetic wire navigation with the conventional wire technique for percutaneous coronary intervention of chronic total occlusions: a randomised, controlled study.Heart and vessels · 2016Trial
- Practical Guide to Percutaneous Biopsy with Contrast-Enhanced Mammography: From Planning to Post-Procedural Management.Diagnostics (Basel, Switzerland) · 2026Review
- Update on Contrast-Induced Nephropathy: Recent Developments in Its Prevention, Early Diagnosis, and Therapy.Medicina (Kaunas, Lithuania) · 2026Review
- Predictive Performance of the Aggregate Index of Systemic Inflammation for Contrast-Induced Nephropathy After PCI in Elderly ACS Patients.Medicina (Kaunas, Lithuania) · 2026Article
- Congestion, but not low cardiac output, is independently associated with acute kidney injury following contrast agent exposure.Frontiers in cardiovascular medicine · 2026Article
- Predictive value of the uric acid-to-albumin ratio for contrast-induced nephropathy after percutaneous coronary intervention and construction of a clinical prediction model in patients with coronary artery disease.Frontiers in cardiovascular medicine · 2026Article
- Biomarkers in Contrast-Induced Nephropathy: Advances in Early Detection, Risk Assessment, and Prevention Strategies.International journal of molecular sciences · 2025Review
- Risk of acute kidney injury following repeated contrast exposure in trauma patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Prediction of post-contrast acute kidney injury by bedside ultrasonography.BMC emergency medicine · 2025Observational
- Role of Mechanical Circulatory Support in Complex High-Risk and Indicated Percutaneous Coronary Intervention: Current Indications, Device Options, and Potential Complications.Journal of clinical medicine · 2024Review
- Navigating nephrotoxic waters: A comprehensive overview of contrast-induced acute kidney injury prevention.World journal of radiology · 2024Review
- Absolute and relative GFR and contrast medium dose/GFR ratio: cornerstones when predicting the risk of acute kidney injury.European radiology · 2024Article
- Prevention of Contrast-induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention.Current cardiology reviews · 2024Review
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesThis study sought to validate a pharmacokinetically derived measure of the risk of an early increase in serum creatinine after percutaneous coronary intervention (PCI).
backgroundThe ratio of the volume of contrast media to the creatinine clearance (V/CrCl) has been shown to correlate with the area under the curve of contrast media concentration over time.
methodsWe calculated V/CrCl in 3,179 consecutive patients undergoing PCI. An increase in serum creatinine of >0.5 mg/dl by 24 to 48 h was considered abnormal. Receiver-operator characteristic methods were used to identify the optimal sensitivity and specificity for the observed range of V/CrCl. The predictive value of V/CrCl for the risk of an early increase in creatinine was assessed using multivariable logistic regression.
resultsThe overall incidence of an abnormal, early increase in creatinine was 1.5%. The mean and median values of V/CrCl for patients with (mean 5.2 +/- 4.4, median 4.3, interquartile range 2.7 to 6.0) and without (mean 3.0 +/- 2.0, median 2.5, interquartile range 1.7 to 3.8) an early creatinine increase were each significantly (p < 0.001) different between groups. Furthermore, there was a significant association between V/CrCl and an early increase in creatinine (overall and trend, p < 0.001). The receiver-operator characteristic curve analysis indicated that a V/CrCl ratio of 3.7 was a fair discriminator for the early creatinine increase (C-statistic 0.69). After adjusting for other known predictors of post-PCI creatinine increase, V/CrCl > or =3.7 remained significantly associated with an early abnormal increase in serum creatinine (odds ratio 3.84; 95% confidence interval 2.0 to 7.3, p < 0.001).
conclusionsA V/CrCl ratio >3.7 was a significant and independent predictor of an early abnormal increase in serum creatinine after PCI in this unselected patient population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.