Evidence map›Paper›PMID 17698691›Full record

ArticleArchives of internal medicine

Obesity, waist circumference, weight change, and the risk of psoriasis in women: Nurses' Health Study II.

Arathi R Setty, Gary Curhan, Hyon K Choi

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Archives of internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT07443956. Cited by 175 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 5 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07443956 narecruiting

Combination of Biologic and Anti-obesity Therapies in Psoriatic Arthritis

Ran2026Enrolled45Registered outcomes5Posted comparisons0ConditionsObesity & Overweight, Psoriatic Arthritis (PsA)ArmsIxekizumab, Tirzepatide
PMID 34076348PMID 15708927PMID 22562978PMID 22586165PMID 31209855PMID 31292564PMID 33147607PMID 33423070PMID 34300360PMID 34453579PMID 36264448PMID 37667975other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 5 syntheses or guidelines pooled it, 479 citations in OpenAlex.

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115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Arathi R SettyDepartment of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Gary Curhan
Hyon K Choi
Massachusetts General Hospital · US

Funding

Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
Research Training in Rheumatology at Massachusetts General HospitalT32AR007258 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDREW D LUSTER · 1986 to 2026
$6.9M
NCI NIH HHS CA50385NIAMS NIH HHS 5 T32 AR007258-29
6 · The paper itself

Abstract

backgroundPsoriasis is a common, chronic, inflammatory skin disorder. Higher adiposity may increase the risk of psoriasis, but, to our knowledge, no prospective data are available on this relationship.

methodsWe prospectively examined the relationships between body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight change, waist circumference, hip circumference, waist-hip ratio, and incident psoriasis in 78 626 women over a 14-year period (1991-2005) in the Nurses' Health Study II. The primary outcome was incident, self-reported, physician-diagnosed psoriasis.

resultsDuring the 14 years of follow-up, there were 892 self-reported incident cases of psoriasis. There was a graded positive association between BMI measured at multiple time points and the risk of incident psoriasis. When we analyzed BMI updated every 2 years, compared with a BMI of 21.0 through 22.9, the multivariate relative risks of psoriasis were 1.40 (95% confidence interval [CI], 1.13-1.73) for a BMI of 25.0 through 29.9; 1.48 (95% CI, 1.15-1.91) for a BMI of 30.0 through 34.9; and 2.69 (95% CI, 2.12-3.40) for a BMI of 35.0 or greater (P for trend, < .001). For BMI at the age of 18 years, the multivariate relative risk for the top BMI category (> or = 30.0) was 1.73 (95% CI, 1.24-2.41) and that for a lower BMI category (< 21.0) was 0.76 (95% CI, 0.65-0.90) (P for trend, < .001). Weight gain from the age of 18 years, higher waist circumference, hip circumference, and waist-hip ratio were all associated with a higher risk of incident psoriasis (all P values for trend, < .001).

conclusionThis large prospective study indicates that increased adiposity and weight gain are strong risk factors for incident psoriasis in women.

Indexed as

AdultBody WeightBody Weights and MeasuresFemaleHumansIncidenceObesityProspective StudiesPsoriasisRisk Factors

Identifiers

PMID17698691
OpenAlexW1991748889

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.