ArticleJournal of cellular and molecular medicine
Close relation of arterial ICC-like cells to the contractile phenotype of vascular smooth muscle cell.
Article in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
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- Ultrastructural and Immunohistochemical Features of Telocytes in Placental Villi in Preeclampsia.Scientific reports · 2018Article
- Yersinia pestis YopK Inhibits Bacterial Adhesion to Host Cells by Binding to the Extracellular Matrix Adaptor Protein Matrilin-2.Infection and immunity · 2017Article
- Calcium Signaling in Interstitial Cells: Focus on Telocytes.International journal of molecular sciences · 2017Review
- Functional and morphological properties of pericytes in suburothelial venules of the mouse bladder.British journal of pharmacology · 2012Article
- Resident phenotypically modulated vascular smooth muscle cells in healthy human arteries.Journal of cellular and molecular medicine · 2012Article
- Identification of telocytes in the lamina propria of rat duodenum: transmission electron microscopy.Journal of cellular and molecular medicine · 2011Article
- TELOCYTES - a case of serendipity: the winding way from Interstitial Cells of Cajal (ICC), via Interstitial Cajal-Like Cells (ICLC) to TELOCYTES.Journal of cellular and molecular medicine · 2010Article
- A distinct type of cell in myocardium: interstitial Cajal-like cells (ICLCs).Journal of cellular and molecular medicine · 2009Article
- Rate-sensitive contractile responses of lymphatic vessels to circumferential stretch.The Journal of physiology · 2009Article
- Mesenchymal stem cells and cardiac repair.Journal of cellular and molecular medicine · 2008Review
- Interstitial cells from rat middle cerebral artery belong to smooth muscle cell type.Journal of cellular and molecular medicineArticle
- Myocardial interstitial Cajal-like cells (ICLC) and their nanostructural relationships with intercalated discs: shed vesicles as intermediates.Journal of cellular and molecular medicineArticle
- Interstitial Cajal-like cells (ICLC) in myocardial sleeves of human pulmonary veins.Journal of cellular and molecular medicineArticle
- Interstitial Cajal-like cells in rat mesentery: an ultrastructural and immunohistochemical approach.Journal of cellular and molecular medicineArticle
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
This work aimed to establish the lineage of cells similar to the interstitial cells of Cajal (ICC), the arterial ICC-like (AIL) cells, which have recently been described in resistance arteries, and to study their location in the artery wall. Segments of guinea-pig mesenteric arteries and single AIL cells freshly isolated from them were used. Confocal imaging of immunostained cells or segments and electron microscopy of artery segments were used to test for the presence and cellular localization of selected markers, and to localize AIL cells in intact artery segments. AIL cells were negative for PGP9.5, a neural marker, and for von Willebrand factor (vWF), an endothelial cell marker. They were positive for smooth muscle alpha-actin and smooth muscle myosin heavy chain (SM-MHC), but expressed only a small amount of smoothelin, a marker of contractile smooth muscle cells (SMC), and of myosin light chain kinase (MLCK), a critical enzyme in the regulation of smooth muscle contraction. Cell isolation in the presence of latrunculin B, an actin polymerization inhibitor, did not cause the disappearance of AIL cells from cell suspension. The fluorescence of basal lamina protein collagen IV was comparable between the AIL cells and the vascular SMCs and the fluorescence of laminin was higher in AIL cells compared to vascular SMCs. Moreover, cells with thin processes were found in the tunica media of small resistance arteries using transmission electron microscopy. The results suggest that AIL cells are immature or phenotypically modulated vascular SMCs constitutively present in resistance arteries.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.