ArticleDiabetologia1991
In vivo use of neutral radiolabelled molecular probes to evaluate blood-ocular barrier integrity in normal and streptozotocin-diabetic rats.
Article in Diabetologia, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 6 citations in OpenAlex.
- Biochemical Changes in Anterior Chamber of the Eye in Diabetic Patients-A Review.Journal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Evidence suggests that the consequences of diabetes mellitus are numerous and that net changes in ocular barrier permeability are necessarily complex functions of changes at specific anatomical loci. In this study we explore changes in blood-aqueous and vitreous permeability in streptozotocin-diabetic rats using five stable radiolabelled probes. Three probes, (3H)-L-glucose, (14C)-sucrose and (14C)-carboxylinulin are relatively large molecules and are expected to move into ocular humours via paracellular routes. Two probes, (14C)-urea and (14C)-glycerol, are small and likely have a trans-cellular component to permeability. Pulse-chase kinetic studies follow the appearance of test molecules into ocular humours with rate constants estimated via linear modelling. Larger neutral probes L-glucose, sucrose and carboxylinulin entered the aqueous humour of control rats slowly via routes that presumably circumvent tight-junctioned barriers. These slow-entry rates were found to increase in diabetic animals suggesting an increase in passive paracellular permeability with significant variation among animals. In contrast, aqueous entry rates of smaller probes urea and glycerol were decreased in diabetic animals suggesting that these probes cross membranes and cells less efficiently in diabetic animals. The magnitude of these changes increased with the length of exposure to diabetes. Paralleling the aqueous humour studies, we found a significant but variable increase in vitreous entry rate with L-glucose, sucrose and carboxylinulin, but a decrease in entry rates with small probes urea and glycerol. These results suggests that diabetes-related blood-ocular permeability changes are complex and depend on the size and properties of the probe as well as the degree of diabetes exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.