ReviewCanadian family physician Medecin de famille canadien2007
Not enough vitamin D: health consequences for Canadians.
Review in Canadian family physician Medecin de famille canadien, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03665116 (Effects of Arginine on Osteoarthritis), which is not on this map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Arginine on Osteoarthritis: A Pilot Clinical Trial
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Vitamin D, calcium or a combination of vitamin D and calcium for the treatment of nutritional rickets in children.The Cochrane database of systematic reviews · 2020Pooled it
- Pooled it
- Does vitamin D affect risk of developing autoimmune disease?: a systematic review.Seminars in arthritis and rheumatism · 2011Pooled it
- Trial
- A randomized, controlled trial evaluating the efficacy of an online intervention targeting vitamin D intake, knowledge and status among young adults.The international journal of behavioral nutrition and physical activity · 2016Trial
- Relationship between vitamin D status, glycaemia and nephropathy in adults with type 2 diabetes mellitus.BMC endocrine disorders · 2026Article
- The association of VDR gene polymorphisms with serum vitamin D levels and injury predisposition in elite athletes of Kazakhstan.European journal of applied physiology · 2026Article
- What is known about the effects of vitamin D in neuropsychiatric lupus?Advances in rheumatology (London, England) · 2024Review
- Potential Effects of an Exoskeleton-Assisted Overground Walking Program for Individuals With Spinal Cord Injury Who Uses a Wheelchair on Imaging and Serum Markers of Bone Strength: Pre-Post Study.JMIR rehabilitation and assistive technologies · 2024Article
- Nutritional Support for Alcoholic Liver Disease.Nutrients · 2023Review
- Hypovitaminosis D in migrant children in Switzerland: a retrospective study.European journal of pediatrics · 2021Article
- Article
- The Preoperative Supplementation With Vitamin D Attenuated Pain Intensity and Reduced the Level of Pro-inflammatory Markers in Patients After Posterior Lumbar Interbody Fusion.Frontiers in pharmacology · 2019Article
- Acute hepatologic and nephrologic effects of calcitriol in Syrian golden hamster (Mesocricetus auratus).Acta biochimica Polonica · 2018Article
- The Importance of Magnesium in Clinical Healthcare.Scientifica · 2017Review
- Vitamin D, Essential Minerals, and Toxic Elements: Exploring Interactions between Nutrients and Toxicants in Clinical Medicine.TheScientificWorldJournal · 2015Review
- Vitamin D: deficiency, sufficiency and toxicity.Nutrients · 2013Review
- Vitamin D status of refugees arriving in Canada: findings from the Calgary Refugee Health Program.Canadian family physician Medecin de famille canadien · 2013Article
- Genome-wide association study of infectious bovine keratoconjunctivitis in Angus cattle.BMC genetics · 2013Article
- The immunoregulatory function of vitamin D: implications in chronic kidney disease.Nature reviews. Nephrology · 2012Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo review the evidence on vitamin D (VTD) insufficiency and deficiency from a Canadian perspective and to highlight some of the known and evolving implications of insufficiency or deficiency for health. QUALITY OF EVIDENCE: PubMed was searched for articles on VTD insufficiency or deficiency and the role they play in various diseases and conditions. Level I and II evidence indicates that lack of VTD has a major role in short- and long-latency diseases. MAIN MESSAGE: The long winters in Canada and lack of exposure to the sun contribute to lower levels of VTD among Canadians in late winter and spring. Currently recommended levels of fortification and supplementation are likely not high enough to restore adequate levels of VTD in the body. Repletion and maintenance therapy might be needed.
conclusionMany Canadians are at risk of VTD insufficiency or deficiency. Assessment of VTD status is important because optimal levels of VTD have been determined for various conditions. Low levels of VTD have negative implications for bone health and the health of other cell types.
Indexed as
Identifiers
17872747PMC1949171What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.