Evidence map›Paper›PMID 17934153›Full record

ArticleDiabetes care2008

Is glycemic control improving in U.S. adults?

Thomas J Hoerger, Joel E Segel, Edward W Gregg, Jinan B Saaddine

4 registry-linked trialsOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Diabetes care, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 186 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed, 6 pooled it
22.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02613897 nacompletedstarted 2016, after this paper: background citation

A 16-wk, Uni-center, Randomized, Double-blind, Parallel, Phase 3b Trial to Evaluate Efficacy of Saxagliptin + Dapagliflozin vs.Dapagliflozin With Regard to EGP in T2DM With Insufficient Glycemic Control on Metformin+/-Sulfonylurea Therapy

Ran2016Enrolled56Registered outcomes9Posted comparisons0ConditionsDiabetes Mellitus, Type 2Armsdapagliflozin, Placebo, Saxagliptin
PMID 24463448PMID 9742977PMID 21781152PMID 18726829PMID 25425451PMID 21114605PMID 24947443PMID 23589542PMID 23863067PMID 23992601PMID 21410628PMID 25370334other papers from this trial
Open the trial in the graph
NCT02887677 phase4terminatedstarted 2016, after this paper: background citation

A Study of the Effects of Dapagliflozin on Ambulatory Aortic Pressure, Arterial Stiffness and Urine Albumin Excretion in Patients With Type 2 Diabetes

Ran2016Enrolled85Registered outcomes9Posted comparisons0ConditionsDiabetes MellitusArmsdapagliflozin, Placebo
PMID 22411919PMID 24919526PMID 24745924PMID 25054271PMID 12748858PMID 12802026PMID 16306358PMID 17000623PMID 17130190PMID 18256578PMID 18268136PMID 19336687other papers from this trial
Open the trial in the graph
NCT02459561 naunknown statusnot on this mapstarted 2015, after this paper: background citation

A Randomised Controlled Trial of a Duodenal Sleeve Bypass Device (EndoBarrier)Compared With Standard Medical Therapy for the Management of Obese Subjects With Type 2 Diabetes

TypeinterventionalSponsorImperial College LondonRan2015 to 2019Enrolled170ConditionsOverweight and Obesity, DiabetesArmsEndoBarrier TM Gastrointestinal Liner, Best Medical Care
NCT03455985 naterminatednot on this mapstarted 2018, after this paper: background citation

Effectiveness of a Diabetes Focused Discharge Order Set Among Poorly Controlled Hospitalized Patients Transitioning to Glargine U300 Insulin

TypeinterventionalSponsorOhio State UniversityRan2018 to 2020Enrolled158ConditionsDiabetes Mellitus, Type 2, Patient Discharge, Blood Glucose, Low, Blood Glucose, HighArmsDischarge Order Set (DOS), Enhanced Standard Care (ESC)
3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 6 syntheses or guidelines pooled it, 480 citations in OpenAlex.

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  20. Mobile phone-based video messages for diabetes self-care support.Journal of diabetes science and technology · 2012
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126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Thomas J HoergerRTI-UNC Center of Excellence in Health Promotion Economics, RTI International, 3040 Cornwallis Rd., P.O. Box 12194, Research Triangle Park, NC 27709, USA. tjh@rti.org
Joel E Segel
Edward W Gregg
Jinan B Saaddine
Centers for Disease Control and Prevention · USRTI International · US

Funding

PHS HHS 200-2002-00776
6 · The paper itself

Abstract

objectiveThe purpose of this study was to examine whether glycemic control has improved in recent years among individuals with diagnosed diabetes. RESEARCH DESIGN AND

methodsWe examined trends in A1C levels for adults with diagnosed diabetes using three consecutive waves of the National Health and Nutrition Examination Survey (NHANES): 1999-2000, 2001-2002, and 2003-2004. We estimated mean A1C levels and the proportion with A1C <7.0, <8.0, and <9.0%. We used multivariate regression to test whether A1C levels differed by NHANES wave after controlling for other factors. Multivariate dichotomous logistic regression and predictive margins were used to test whether the percentages of individuals with diabetes in selected A1C intervals differed by NHANES wave.

resultsMean A1C levels among individuals with diagnosed diabetes declined from 7.82% in 1999-2000 to 7.47 and 7.18% in 2001-2002 and 2003-2004, respectively. After controlling for demographics and diabetes duration, A1C levels were 0.308 (P = 0.20) and 0.511 (P = 0.03) percentage points lower in 2001-2002 and 2003-2004, respectively, than in 1999-2000. The logistic results indicated corresponding improvements over time: the predictive margin for having A1C <7.0% increased from 37.0% in 1999-2000 to 49.7% in 2001-2002 and to 55.7% in 2003-2004.

conclusionsGlycemic control improved between 1999 and 2004. This trend may represent an important improvement in diabetes care and is encouraging for future reduction of diabetes-related complications.

Indexed as

AdultAgedBlood GlucoseBody Mass IndexDiabetes MellitusEthnicityFemaleGlycated HemoglobinHealth SurveysHumansMaleMiddle AgedMultivariate AnalysisRegression AnalysisSocioeconomic FactorsUnited StatesBlood GlucoseGlycated Hemoglobin

Identifiers

PMID17934153
OpenAlexW2162037642

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.