ArticleNucleic acids research2008
Nuclear receptor interaction protein, a coactivator of androgen receptors (AR), is regulated by AR and Sp1 to feed forward and activate its own gene expression through AR protein stability.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Targeting the Fatty Acid Binding Protein 5-Specificity Protein 1 Axis Restores Enzalutamide Sensitivity by Suppressing Androgen Receptor/Androgen Receptor Splice Variant 7 Signaling: Implications for Prostate Cancer Therapy.World journal of oncology · 2026Article
- Activation of Genes by Nuclear Receptor/Specificity Protein (Sp) Interactions in Cancer.Cancers · 2025Review
- The Innovative Role of Nuclear Receptor Interaction Protein in Orchestrating Invadosome Formation for Myoblast Fusion.Journal of cachexia, sarcopenia and muscle · 2024Article
- Regulation of the gap junction interplay during postnatal development in the rat epididymis.Cell and tissue research · 2024Article
- AAV-NRIP gene therapy ameliorates motor neuron degeneration and muscle atrophy in ALS model mice.Skeletal muscle · 2024Article
- Second generation androgen receptor antagonist, TQB3720 abrogates prostate cancer growthFrontiers in pharmacology · 2023Article
- Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis.Journal of cachexia, sarcopenia and muscle · 2021Article
- MicroRNAs and Androgen Receptor: Emerging Players in Breast Cancer.Frontiers in genetics · 2019Review
- Muscle-restricted nuclear receptor interaction protein knockout causes motor neuron degeneration through down-regulation of myogenin at the neuromuscular junction.Journal of cachexia, sarcopenia and muscle · 2018Article
- A Selection of Important Genes and Their Correlated Behavior in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2018Article
- The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness.Molecular cancer · 2017Article
- Sp1 transcription factor promotes TMEPAI gene expression and contributes to cell proliferation.Cell proliferation · 2016Article
- Sp1 sites in the noncoding control region of BK polyomavirus are key regulators of bidirectional viral early and late gene expression.Journal of virology · 2015Article
- Androgen up-regulates vascular endothelial growth factor expression in prostate cancer cells via an Sp1 binding site.Molecular cancer · 2013Article
- RACK1, A multifaceted scaffolding protein: Structure and function.Cell communication and signaling : CCS · 2011Article
- NRIP, a novel calmodulin binding protein, activates calcineurin to dephosphorylate human papillomavirus E2 protein.Journal of virology · 2011Article
- Differential regulation of steroid nuclear receptor coregulator expression between normal and neoplastic prostate epithelial cells.The Prostate · 2010Article
- Androgen modulation of coregulator expression in prostate cancer cells.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Nuclear Receptor Interaction Protein (NRIP) expression assay using human tissue microarray and immunohistochemistry technology confirming nuclear localization.Journal of experimental & clinical cancer research : CR · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously, we found a novel gene, nuclear receptor interaction protein (NRIP), a transcription cofactor that can enhance an AR-driven PSA promoter activity in a ligand-dependent manner in prostate cancer cells. Here, we investigated NRIP regulation. We cloned a 413-bp fragment from the transcription initiation site of the NRIP gene that had strong promoter activity, was TATA-less and GC-rich, and, based on DNA sequences, contained one androgen response element (ARE) and three Sp1-binding sites (Sp1-1, Sp1-2, Sp1-3). Transient promoter luciferase assays, chromatin immunoprecipitation and small RNA interference analyses mapped ARE and Sp1-2-binding sites involved in NRIP promoter activation, implying that NRIP is a target gene for AR or Sp1. AR associates with the NRIP promoter through ARE and indirectly through Sp1-binding site via AR-Sp1 complex formation. Thus both ARE and Sp1-binding site within the NRIP promoter can respond to androgen induction. More intriguingly, NRIP plays a feed-forward role enhancing AR-driven NRIP promoter activity via NRIP forming a complex with AR to protect AR protein from proteasome degradation. This is the first demonstration that NRIP is a novel AR-target gene and that NRIP expression feeds forward and activates its own expression through AR protein stability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.