ArticleDiabetologia2008
Mean blood glucose compared with HbA1c in the prediction of cardiovascular disease in patients with type 1 diabetes.
Article in Diabetologia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02879409 (Does Glycated Hemoglobin Variability in Type 2 Diabetes Differ Depending on the Diabetes Treatment Threshold Used in the Qatari Population), which is not on this map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Does Glycated Hemoglobin Variability in Type 2 Diabetes Differ Depending on the Diabetes Treatment Threshold Used in the Qatari Population: Implication on Diabetes Complication Risk?
Who cites it
31 citing papers in PubMed, 84 citations in OpenAlex.
- Effect of Date Fruit Consumption on the Glycemic Control of Patients with Type 2 Diabetes: A Randomized Clinical Trial.Nutrients · 2022Trial
- Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial.Diabetes care · 2017Trial
- Continuous glucose monitoring after islet transplantation in type 1 diabetes: an excellent graft function (β-score greater than 7) Is required to abrogate hyperglycemia, whereas a minimal function is necessary to suppress severe hypoglycemia (β-score greater than 3).The Journal of clinical endocrinology and metabolism · 2012Trial
- Rapid improvement of glycemic control in type 2 diabetes using weekly intensive multifactorial interventions: structured glucose monitoring, patient education, and adjustment of therapy-a randomized controlled trial.Diabetes technology & therapeutics · 2011Trial
- Improving the estimation of mealtime insulin dose in adults with type 1 diabetes: the Normal Insulin Demand for Dose Adjustment (NIDDA) study.Diabetes care · 2011Trial
- Primary graft function, metabolic control, and graft survival after islet transplantation.Diabetes care · 2009Trial
- Mind the gap: Ongoing inequalities in glycaemic levels in young people living with Type 1 diabetes across England and Wales.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes.Nature communications · 2026Article
- Mitigating iftar-related glycemic excursions in adolescents and young adults with type 1 diabetes on MiniMed™ 780G advanced hybrid closed loop system: a randomized clinical trial for adjunctive oral vildagliptin therapy during Ramadan fasting.Diabetology & metabolic syndrome · 2023Article
- The association between time in the glucose target range and abnormal ankle-brachial index: a cross-sectional analysis.Cardiovascular diabetology · 2022Article
- Associations of Plasma Glucagon Levels with Estimated Glomerular Filtration Rate, Albuminuria and Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2021Article
- Article
- Impact of free-living pattern of sedentary behaviour on intra-day glucose regulation in type 2 diabetes.European journal of applied physiology · 2020Article
- Hypoglycemia does not affect the progression of preclinical atherosclerosis in subjects with type 2 diabetes.PloS one · 2019Article
- Glycemic variability predicts inflammation in adolescents with type 1 diabetes.Journal of pediatric endocrinology & metabolism : JPEM · 2016Article
- Independent association between glycated hemoglobin and arterial stiffness in healthy men.Journal of diabetes investigation · 2016Article
- Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes.World journal of diabetes · 2015Review
- Clinical Implications of Glucose Variability: Chronic Complications of Diabetes.Endocrinology and metabolism (Seoul, Korea) · 2015Review
- Is type 2 diabetes really resolved after laparoscopic sleeve gastrectomy? Glucose variability studied by continuous glucose monitoring.Journal of diabetes research · 2015Article
- Glycemic variability and oxidative stress: a link between diabetes and cardiovascular disease?International journal of molecular sciences · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisIt is not known whether mean blood glucose (MBG) predicts the risk of macrovascular complications in diabetes any differently from HbA1c. In this study we therefore analysed data from the Diabetes Control and Complications Trial (DCCT) to assess the relationship between MBG, HbA1c and glucose variability with regard to the risk of cardiovascular disease in patients with type 1 diabetes.
methodsPre- and postprandial seven-point glucose profiles were collected quarterly during the DCCT in 1441 individuals. The relationship between time to first cardiovascular event and MBG, HbA1c and daily SD of blood glucose was assessed by Cox regression after adjusting for the known risk factors of macrovascular disease and the treatment groups of the patients.
resultsCox regression showed MBG to be predictive of a cardiovascular event (p=0.019), but not HbA1c (p=0.858). A rise of 1 mmol/l in MBG was associated with an 11% rise in cardiovascular risk. MBG remained highly predictive (p=0.015) even after adjustment for HbA1c values and glucose variability. CONCLUSIONS/
interpretationThis study has shown that during the DCCT MBG was a better predictor of the macrovascular complications of type 1 diabetes than HbA1c. It indicates that the cardiovascular risk associated with hyperglycaemia appeared within the time period of the study and that blood glucose rather than HbA1c may be the preferred means of assessing this risk.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.