ArticleInflammation2008
Characterizing extravascular neutrophil migration in vivo in the iris.
Article in Inflammation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- A novel bispecific molecule delivered by recombinant AAV2 suppresses ocular inflammation and choroidal neovascularization.Journal of cellular and molecular medicine · 2017Article
- Roscovitine ameliorates endotoxin-induced uveitis through neutrophil apoptosis.Molecular medicine reports · 2016Article
- Gene therapy with the caspase activation and recruitment domain reduces the ocular inflammatory response.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- Oral delivery of ACE2/Ang-(1-7) bioencapsulated in plant cells protects against experimental uveitis and autoimmune uveoretinitis.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Integrin-dependent neutrophil migration in the injured mouse cornea.Experimental eye research · 2014Article
- Why HLA-B27? My thirty-year quest: the Friedenwald lecture.Investigative ophthalmology & visual science · 2011Article
- Contrasting ocular effects of local versus systemic endotoxin.Investigative ophthalmology & visual science · 2011Article
- Article
- Eicosapentaenoic acid suppresses ocular inflammation in endotoxin-induced uveitis.Molecular vision · 2010Article
- Novel molecular imaging approach for subclinical detection of iritis and evaluation of therapeutic success.The American journal of pathology · 2010Article
- NOD1 expression in the eye and functional contribution to IL-1beta-dependent ocular inflammation in mice.Investigative ophthalmology & visual science · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Extravascular neutrophil migration is poorly characterized in vivo. To test the hypothesis that this migration is a non-random process, we used videomicroscopy to monitor neutrophils in irises of living mice with endotoxin-induced uveitis (EIU). Paths of individual cells were analyzed. Nearly all of these cells were moving in divergent directions, and mean displacement plots indicated that the predominant movement was random. The paths of some cells were fit to bivariate autoregressive integrated moving average models that revealed at least two modes of movement: random search and linear trend. Cell speed was significantly reduced by the actin inhibitor, cytochalasin D. The pattern of migration for neutrophils is in marked contrast to what we previously described for antigen-presenting cells in the iris, but somewhat resembles recent descriptions for T cells within a lymph node. Characterization of extravascular migration of neutrophils has important implications for understanding infection and immunity.
Indexed as
Identifiers
18196451What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.