ArticleClinical chemistry2008
Plasma polyunsaturated fatty acids and the decline of renal function.
Article in Clinical chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts.BMJ (Clinical research ed.) · 2023Pooled it
- GFR in Healthy Aging: an Individual Participant Data Meta-Analysis of Iohexol Clearance in European Population-Based Cohorts.Journal of the American Society of Nephrology : JASN · 2020Pooled it
- The effect of n-3 long-chain polyunsaturated fatty acid supplementation on urine protein excretion and kidney function: meta-analysis of clinical trials.The American journal of clinical nutrition · 2009Pooled it
- Effect of omega-3 fatty acids on kidney function after myocardial infarction: the Alpha Omega Trial.Clinical journal of the American Society of Nephrology : CJASN · 2014Trial
- Assessing the Prevalence and Pattern of Dyslipidemia Among Maintenance Hemodialysis Patients in Selected Areas of Bangladesh: A Multicenter Cross-Sectional Study.Public health challenges · 2026Article
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- Differences in red blood cell fatty acid profiles by type 2 diabetes status in early-stage chronic kidney disease.Scientific reports · 2026Article
- Linoelaidic acid alleviates COM-induced kidney injury and crystal deposition via the PPARγ/MAPK signaling pathway.Urolithiasis · 2025Article
- Review
- Habitual Fish Oil Supplementation and Incident Chronic Kidney Disease in the UK Biobank.Nutrients · 2022Article
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- Nutrition, Immunology, and Kidney: Looking Beyond the Horizons.Current nutrition reports · 2022Review
- Dietary fat intake and risk of disabling hearing impairment: a prospective population-based cohort study.European journal of nutrition · 2022Article
- Association between the metabolic profile of serum fatty acids and diabetic nephropathy: a study conducted in northeastern China.Therapeutic advances in endocrinology and metabolism · 2022Article
- Determinants of the Evolution of Kidney Function With Age.Kidney international reports · 2021Article
- A Matched Case-Control Study of Noncholesterol Sterols and Fatty Acids in Chronic Hemodialysis Patients.Metabolites · 2021Article
- Dietary Lipids and Dyslipidemia in Chronic Kidney Disease.Nutrients · 2021Review
- Plasma and urinary FJournal of feline medicine and surgery · 2021Article
- Lipidomics reveals association of circulating lipids with body mass index and outcomes in IgA nephropathy patients.Journal of molecular cell biology · 2021Article
- Predictors of oxylipins in a healthy pediatric population.Pediatric research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundRecent studies suggest an association between polyunsaturated fatty acids (PUFAs) and the development of chronic kidney disease. The aim of this study was to examine the relationship between PUFAs and renal function in older adults.
methodsWe performed a cross-sectional and prospective analysis of 931 adults, > or = 65 years old, enrolled in the InCHIANTI study, a population-based cohort in Tuscany, Italy. Plasma PUFAs were measured at enrollment, and creatinine clearance was estimated by the Cockcroft-Gault equation at baseline and after 3-year follow-up.
resultsAt enrollment, participants with higher creatinine clearance had higher concentrations of HDL cholesterol, total plasma PUFAs, plasma n-3 fatty acid (FA), and plasma n-6 FA and lower triglycerides. From enrollment to the 3-year follow-up visit, creatinine clearance declined by 7.8 (12.2) mL/min (P <0.0001). Baseline total plasma PUFAs, n-3 FA, n-6 FA, and linoleic, linolenic, and arachidonic acids were strong independent predictors of less steep decline in creatinine clearance from baseline to follow-up (P <0.0001, after adjusting for baseline creatinine clearance). After adjusting for baseline creatinine, baseline total plasma PUFAs, n-3 FA, and linoleic, linolenic, and arachidonic acids were negatively associated with creatinine at 3-year follow-up. Participants with higher plasma PUFAs at enrollment had a lower risk of developing renal insufficiency, defined by a creatinine clearance <60 mL/min, during 3-year follow-up.
conclusionHigh PUFA concentrations, both n-3 FA and n-6 FA, may attenuate the age-associated decline in renal function among older community-dwelling women and men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.